4rye
From Proteopedia
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==The crystal structure of D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium tuberculosis H37Rv== | ==The crystal structure of D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium tuberculosis H37Rv== | ||
| - | <StructureSection load='4rye' size='340' side='right' caption='[[4rye]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='4rye' size='340' side='right'caption='[[4rye]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4rye]] is a 4 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4rye]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RYE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RYE FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.901Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rye FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rye OCA], [https://pdbe.org/4rye PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rye RCSB], [https://www.ebi.ac.uk/pdbsum/4rye PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rye ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DACB2_MYCTU DACB2_MYCTU] Probably cleaves the terminal D-Ala-D-Ala dipeptide of the peptidoglycan stem peptide (Probable). Shows significant D,D-carboxypeptidase activity in vitro (PubMed:22906310). Acts on the synthetic penta-peptide substrate Penta-DAP (L-Ala-gamma-D-Gln-DAP-D-Ala-D-Ala). Shows also weak activity on Penta-Lys (L-Ala-gamma-Glu-L-Lys-D-Ala-D-Ala) (PubMed:22906310). The catalytic domain binds weakly to peptidoglycan in vitro (PubMed:25551456). Plays an important role in the maintenance of colony morphology and cell wall permeability and integrity (PubMed:25467937).<ref>PMID:22906310</ref> <ref>PMID:25467937</ref> <ref>PMID:25551456</ref> <ref>PMID:22906310</ref> | ||
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| + | ==See Also== | ||
| + | *[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]] | ||
| + | *[[Penicillin-binding protein 3D structures|Penicillin-binding protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Cuff | + | [[Category: Mycobacterium tuberculosis H37Rv]] |
| - | [[Category: Hatzos-Skintges | + | [[Category: Cuff M]] |
| - | [[Category: Jedrzejczak | + | [[Category: Hatzos-Skintges C]] |
| - | [[Category: Joachimiak | + | [[Category: Jedrzejczak R]] |
| - | + | [[Category: Joachimiak A]] | |
| - | + | [[Category: Sacchettini J]] | |
| - | [[Category: Sacchettini | + | [[Category: Tan K]] |
| - | [[Category: Tan | + | |
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Current revision
The crystal structure of D-ALANYL-D-ALANINE CARBOXYPEPTIDASE from Mycobacterium tuberculosis H37Rv
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