This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4s0p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (18:00, 20 September 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (II)==
==Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (II)==
-
<StructureSection load='4s0p' size='340' side='right' caption='[[4s0p]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
+
<StructureSection load='4s0p' size='340' side='right'caption='[[4s0p]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4s0p]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S0P FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4s0p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S0P FirstGlance]. <br>
-
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4s0o|4s0o]], [[1f16|1f16]]</td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.252&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAX, BCL2L4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0p OCA], [https://pdbe.org/4s0p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s0p RCSB], [https://www.ebi.ac.uk/pdbsum/4s0p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0p ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s0p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0p OCA], [http://pdbe.org/4s0p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s0p RCSB], [http://www.ebi.ac.uk/pdbsum/4s0p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0p ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
+
[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 18:
</div>
</div>
<div class="pdbe-citations 4s0p" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4s0p" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
-
[[Category: Gavathiotis, E]]
+
[[Category: Large Structures]]
-
[[Category: Priyadarshi, A]]
+
[[Category: Gavathiotis E]]
-
[[Category: Apoptosis]]
+
[[Category: Priyadarshi A]]
-
[[Category: Apoptosis regulator]]
+
-
[[Category: Autoinhibited dimer]]
+
-
[[Category: Bcl-2 family protein]]
+

Current revision

Crystal Structure of the Autoinhibited Dimer of Pro-apoptotic BAX (II)

PDB ID 4s0p

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4s0p"
Personal tools