1psr

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[[Image:1psr.gif|left|200px]]<br />
 
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<applet load="1psr" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1psr, resolution 1.05&Aring;" />
 
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'''HUMAN PSORIASIN (S100A7)'''<br />
 
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==Overview==
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==HUMAN PSORIASIN (S100A7)==
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BACKGROUND: The S100 family consists of small acidic proteins, belonging, to the EF-hand class of calcium-binding proteins. They are primarily, regulatory proteins, involved in cell growth, cell structure regulation, and signal transduction. Psoriasin (S100A7) is an 11.7 kDa protein that is, highly upregulated in the epidermis of patients suffering from the chronic, skin disease psoriasis. Although its exact function is not known, psoriasin is believed to participate in the biochemical response which, follows transient changes in the cellular Ca2+ concentration. RESULTS: The, three-dimensional structure of holmium-substituted psoriasin has been, determined by multiple anomalous wavelength dispersion (MAD) phasing and, refined to atomic resolution (1.05 A). The structure represents the most, accurately determined structure of a calcium-binding protein. Although the, overall structure of psoriasin is similar to those of other S100 proteins, several important differences exist, mainly in the N-terminal EF-hand, motif that contains a distorted loop and lacks a crucial calcium-binding, residue. It is these minor differences that may account for the different, specificities among members of this family. CONCLUSIONS: The structure of, human psoriasin reveals that this protein, in contrast to other S100, proteins with known structure, is not likely to strongly bind more than, one calcium ion per monomer. The present study contradicts the idea that, calcium binding induces large changes in conformation, as suggested by, previously determined structures of apo forms of S100 proteins. The, substitution of Ca2+ ions in EF-hands by lanthanide ions may provide a, general vehicle for structure determination of S100 proteins by means of, MAD phasing.
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<StructureSection load='1psr' size='340' side='right'caption='[[1psr]], [[Resolution|resolution]] 1.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1psr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSR FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HO:HOLMIUM+ATOM'>HO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1psr OCA], [https://pdbe.org/1psr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1psr RCSB], [https://www.ebi.ac.uk/pdbsum/1psr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S10A7_HUMAN S10A7_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ps/1psr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1psr ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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1PSR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with HO as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: HO. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1PSR OCA].
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*[[S100 proteins 3D structures|S100 proteins 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing., Brodersen DE, Etzerodt M, Madsen P, Celis JE, Thogersen HC, Nyborg J, Kjeldgaard M, Structure. 1998 Apr 15;6(4):477-89. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9562557 9562557]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Brodersen, D.E.]]
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[[Category: Brodersen DE]]
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[[Category: Celis, J.]]
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[[Category: Celis J]]
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[[Category: Etzerodt, M.]]
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[[Category: Etzerodt M]]
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[[Category: Kjeldgaard, M.]]
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[[Category: Kjeldgaard M]]
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[[Category: Madsen, P.]]
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[[Category: Madsen P]]
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[[Category: Nyborg, J.]]
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[[Category: Nyborg J]]
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[[Category: Thoegersen, H.C.]]
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[[Category: Thoegersen HC]]
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[[Category: HO]]
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[[Category: ef-hand protein]]
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[[Category: mad phasing]]
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[[Category: psoriasis]]
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[[Category: s100 protein family]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 16:59:34 2007''
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Current revision

HUMAN PSORIASIN (S100A7)

PDB ID 1psr

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