4zqo

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==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor Q67==
==Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor Q67==
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<StructureSection load='4zqo' size='340' side='right' caption='[[4zqo]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
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<StructureSection load='4zqo' size='340' side='right'caption='[[4zqo]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zqo]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZQO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zqo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZQO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZQO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=Q67:N~2~-(2,3-DICHLOROPHENYL)-N-[2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-YL]-L-ALANINAMIDE'>Q67</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.76&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zqn|4zqn]], [[4zqm|4zqm]], [[4zqp|4zqp]], [[4zqr|4zqr]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PGO:S-1,2-PROPANEDIOL'>PGO</scene>, <scene name='pdbligand=Q67:N~2~-(2,3-DICHLOROPHENYL)-N-[2-(PYRIDIN-4-YL)-1,3-BENZOXAZOL-5-YL]-L-ALANINAMIDE'>Q67</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">guaB, guaB2, Rv3411c, MTCY78.17 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqo OCA], [https://pdbe.org/4zqo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zqo RCSB], [https://www.ebi.ac.uk/pdbsum/4zqo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqo ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zqo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zqo OCA], [http://pdbe.org/4zqo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zqo RCSB], [http://www.ebi.ac.uk/pdbsum/4zqo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zqo ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
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[https://www.uniprot.org/uniprot/IMDH_MYCTU IMDH_MYCTU] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zqo" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zqo" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Myctu]]
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[[Category: Large Structures]]
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[[Category: Anderson, W F]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Structural genomic]]
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[[Category: Anderson WF]]
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[[Category: Gu, M]]
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[[Category: Gu M]]
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[[Category: Hedstrom, L]]
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[[Category: Hedstrom L]]
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[[Category: Joachimiak, A]]
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[[Category: Joachimiak A]]
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[[Category: Kavitha, M]]
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[[Category: Kavitha M]]
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[[Category: Kim, Y]]
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[[Category: Kim Y]]
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[[Category: Makowska-Grzyska, M]]
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[[Category: Makowska-Grzyska M]]
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[[Category: Csgid]]
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[[Category: Delta cb]]
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[[Category: Impdh]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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Current revision

Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the complex with IMP and the inhibitor Q67

PDB ID 4zqo

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