5bow
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==CRYSTAL STRUCTURE OF IL-38== | ==CRYSTAL STRUCTURE OF IL-38== | ||
| - | <StructureSection load='5bow' size='340' side='right' caption='[[5bow]], [[Resolution|resolution]] 1.31Å' scene=''> | + | <StructureSection load='5bow' size='340' side='right'caption='[[5bow]], [[Resolution|resolution]] 1.31Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5bow]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5bow]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BOW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5BOW FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.31Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5bow FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bow OCA], [https://pdbe.org/5bow PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5bow RCSB], [https://www.ebi.ac.uk/pdbsum/5bow PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5bow ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IL1FA_HUMAN IL1FA_HUMAN] Cytokine with immunomodulatory activity. Alone, does not induce cytokine production, but reduces IL22 and IL17A production by T-cells in response to heat-killed Candida albicans. Reduces IL36G-induced production of IL8 by peripheral blood mononuclear cells. Increases IL6 production by dendritic cells stimulated by bacterial lipopolysaccharides (LPS). Ligand for IL-36R/IL1RL2.<ref>PMID:22315422</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Guenther S]] |
| - | [[Category: | + | [[Category: Sundberg EJ]] |
| - | + | ||
| - | + | ||
Current revision
CRYSTAL STRUCTURE OF IL-38
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