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5hi5
From Proteopedia
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==Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists== | ==Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists== | ||
| - | <StructureSection load='5hi5' size='340' side='right' caption='[[5hi5]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='5hi5' size='340' side='right'caption='[[5hi5]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5hi5]] is a 7 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5hi5]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HI5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63Q:(4S,20R)-7-CHLORO-N-METHYL-4-{[(1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]AMINO}-3,18-DIOXO-2,19-DIAZATETRACYCLO[20.2.2.1~6,10~.1~11,15~]OCTACOSA-1(24),6(28),7,9,11(27),12,14,22,25-NONAENE-20-CARBOXAMIDE'>63Q</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=63Q:(4S,20R)-7-CHLORO-N-METHYL-4-{[(1-METHYL-1H-PYRAZOL-5-YL)CARBONYL]AMINO}-3,18-DIOXO-2,19-DIAZATETRACYCLO[20.2.2.1~6,10~.1~11,15~]OCTACOSA-1(24),6(28),7,9,11(27),12,14,22,25-NONAENE-20-CARBOXAMIDE'>63Q</scene>, <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hi5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hi5 OCA], [https://pdbe.org/5hi5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hi5 RCSB], [https://www.ebi.ac.uk/pdbsum/5hi5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hi5 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IL17_HUMAN IL17_HUMAN] Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts. |
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| - | + | ==See Also== | |
| - | + | *[[Interleukin 3D structures|Interleukin 3D structures]] | |
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| - | == | + | |
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Liu S]] |
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Current revision
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
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