UMP/CMP kinase
From Proteopedia
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| - | <StructureSection load='1tev' size='350' side='right' caption='Structure of human UMP/CMP kinase (PDB entry [[1tev]])' scene=''> | + | <StructureSection load='1tev' size='350' side='right' caption='Structure of human UMP/CMP kinase complex with sulfate (PDB entry [[1tev]])' scene='69/698098/Cv/1'> |
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== Function == | == Function == | ||
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== Relevance == | == Relevance == | ||
| - | + | Several cytidine and deoxycytidine analogs are important anticancer and antiviral drugs. These drugs require stepwise phosphorylation to exert their fully therapeutic effect. This phosphorylation is done by UCK<ref>PMID:11912132</ref>. | |
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</StructureSection> | </StructureSection> | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| + | [[1tev]], [[7e9v]] – UCK – human <br /> | ||
[[2ukd]], [[3ukd]], [[1qf9]], [[5ukd]] – smUCK + ADP + CMP – slime mold <br /> | [[2ukd]], [[3ukd]], [[1qf9]], [[5ukd]] – smUCK + ADP + CMP – slime mold <br /> | ||
[[4ukd]] – smUCK + ADP + UDP <br /> | [[4ukd]] – smUCK + ADP + UDP <br /> | ||
[[1uke]] – smUCK + inhibitor<br /> | [[1uke]] – smUCK + inhibitor<br /> | ||
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== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of UMP/CMP kinase
Updated on 20-June-2022
1tev, 7e9v – UCK – human
2ukd, 3ukd, 1qf9, 5ukd – smUCK + ADP + CMP – slime mold
4ukd – smUCK + ADP + UDP
1uke – smUCK + inhibitor
References
- ↑ Pasti C, Gallois-Montbrun S, Munier-Lehmann H, Veron M, Gilles AM, Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur J Biochem. 2003 Apr;270(8):1784-90. PMID:12694191
- ↑ Liou JY, Dutschman GE, Lam W, Jiang Z, Cheng YC. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res. 2002 Mar 15;62(6):1624-31. PMID:11912132
