6bnp
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6bnp is ON HOLD Authors: Gurel, P.S., Alushin, G.A. Description: CryoEM structure of MyosinVI-actin complex in the rigor (nucleotide-free) state [[...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==CryoEM structure of MyosinVI-actin complex in the rigor (nucleotide-free) state== | |
| + | <SX load='6bnp' size='340' side='right' viewer='molstar' caption='[[6bnp]], [[Resolution|resolution]] 4.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6bnp]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BNP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BNP FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bnp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bnp OCA], [https://pdbe.org/6bnp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bnp RCSB], [https://www.ebi.ac.uk/pdbsum/6bnp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bnp ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MYO6_PIG MYO6_PIG] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in polarized epithelial cells. May act as a regulator of F-actin dynamics. May play a role in transporting DAB2 from the plasma membrane to specific cellular targets. Required for structural integrity of inner ear hair cells (By similarity).<ref>PMID:16917816</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Actin 3D structures|Actin 3D structures]] | |
| - | + | *[[Myosin 3D Structures|Myosin 3D Structures]] | |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Alushin | + | __TOC__ |
| + | </SX> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Oryctolagus cuniculus]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Alushin GA]] | ||
| + | [[Category: Gurel PS]] | ||
Current revision
CryoEM structure of MyosinVI-actin complex in the rigor (nucleotide-free) state
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