2bok

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[[Image:2bok.gif|left|200px]]
 
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{{Structure
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==Factor Xa - cation==
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|PDB= 2bok |SIZE=350|CAPTION= <scene name='initialview01'>2bok</scene>, resolution 1.64&Aring;
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<StructureSection load='2bok' size='340' side='right'caption='[[2bok]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Na+Binding+Site+For+Chain+A'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=784:[AMINO+(4-{(3AS,4R,8AS,8BR)-1,3-DIOXO-2-+[3-(TRIMETHYLAMMONIO)+PROPYL]DECAHYDROPYRROLO[3,4-A]+PYRROLIZIN-4-YL}PHENYL)+METHYLENE]AMMONIUM'>784</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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<table><tr><td colspan='2'>[[2bok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BOK FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Coagulation_factor_Xa Coagulation factor Xa], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.6 3.4.21.6] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=784:[AMINO+(4-{(3AS,4R,8AS,8BR)-1,3-DIOXO-2-+[3-(TRIMETHYLAMMONIO)+PROPYL]DECAHYDROPYRROLO[3,4-A]+PYRROLIZIN-4-YL}PHENYL)+METHYLENE]AMMONIUM'>784</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bok OCA], [https://pdbe.org/2bok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bok RCSB], [https://www.ebi.ac.uk/pdbsum/2bok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bok ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bok OCA], [http://www.ebi.ac.uk/pdbsum/2bok PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bok RCSB]</span>
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== Disease ==
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}}
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bo/2bok_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bok ConSurf].
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<div style="clear:both"></div>
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'''FACTOR XA- CATION'''
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==See Also==
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*[[Factor Xa|Factor Xa]]
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== References ==
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==About this Structure==
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<references/>
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2BOK is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BOK OCA].
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__TOC__
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</StructureSection>
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==Reference==
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Quantification of cation-pi interactions in protein-ligand complexes: crystal-structure analysis of Factor Xa bound to a quaternary ammonium ion ligand., Scharer K, Morgenthaler M, Paulini R, Obst-Sander U, Banner DW, Schlatter D, Benz J, Stihle M, Diederich F, Angew Chem Int Ed Engl. 2005 Jul 11;44(28):4400-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15952226 15952226]
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[[Category: Coagulation factor Xa]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Banner, D W.]]
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[[Category: Banner DW]]
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[[Category: Benz, J.]]
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[[Category: Benz J]]
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[[Category: Diederich, F.]]
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[[Category: Diederich F]]
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[[Category: Morgenthaler, M.]]
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[[Category: Morgenthaler M]]
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[[Category: Obst-Sander, U.]]
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[[Category: Obst-Sander U]]
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[[Category: Paulini, R.]]
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[[Category: Paulini R]]
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[[Category: Schaerer, K.]]
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[[Category: Schaerer K]]
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[[Category: Schlatter, D.]]
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[[Category: Schlatter D]]
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[[Category: Stihle, M.]]
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[[Category: Stihle M]]
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[[Category: cation]]
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[[Category: coagulation factor]]
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[[Category: egf-like domain]]
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[[Category: hydrolase]]
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[[Category: inhibitor]]
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[[Category: plasma]]
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[[Category: protease]]
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[[Category: serine protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:31 2008''
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Current revision

Factor Xa - cation

PDB ID 2bok

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