2bp1

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[[Image:2bp1.gif|left|200px]]
 
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{{Structure
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==Structure of the aflatoxin aldehyde reductase in complex with NADPH==
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|PDB= 2bp1 |SIZE=350|CAPTION= <scene name='initialview01'>2bp1</scene>, resolution 2.40&Aring;
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<StructureSection load='2bp1' size='340' side='right'caption='[[2bp1]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Flc+Binding+Site+For+Chain+D'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>
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<table><tr><td colspan='2'>[[2bp1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BP1 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bp1 OCA], [https://pdbe.org/2bp1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bp1 RCSB], [https://www.ebi.ac.uk/pdbsum/2bp1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bp1 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bp1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bp1 OCA], [http://www.ebi.ac.uk/pdbsum/2bp1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bp1 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/ARK72_HUMAN ARK72_HUMAN] Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.<ref>PMID:17591773</ref> <ref>PMID:9576847</ref>
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== Evolutionary Conservation ==
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'''STRUCTURE OF THE AFLATOXIN ALDEHYDE REDUCTASE IN COMPLEX WITH NADPH'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/2bp1_consurf.spt"</scriptWhenChecked>
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2BP1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BP1 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bp1 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bray, J.]]
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[[Category: Bray J]]
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[[Category: Colebrook, S.]]
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[[Category: Colebrook S]]
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[[Category: Debreczeni, J E.]]
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[[Category: Debreczeni JE]]
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[[Category: Delft, F Von.]]
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[[Category: Dubinina E]]
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[[Category: Dubinina, E.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Haroniti A]]
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[[Category: Haroniti, A.]]
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[[Category: Kavanagh K]]
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[[Category: Kavanagh, K.]]
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[[Category: Lukacik P]]
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[[Category: Lukacik, P.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Von Delft F]]
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[[Category: aldo-keto reductase family 7]]
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[[Category: oxidoreductase]]
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[[Category: ssa reductase]]
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[[Category: tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:36 2008''
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Current revision

Structure of the aflatoxin aldehyde reductase in complex with NADPH

PDB ID 2bp1

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