6bpi

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(New page: '''Unreleased structure''' The entry 6bpi is ON HOLD Authors: MADER, P., Mendoza-Sanchez, R., DONG, A., DOBROVETSKY, E., IQBAL, A., CORLESS, V., TEMPEL, W., LIEW, S.K., SMIL, D., DELA S...)
Current revision (09:44, 2 April 2025) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6bpi is ON HOLD
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==Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates==
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<StructureSection load='6bpi' size='340' side='right'caption='[[6bpi]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6bpi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BPI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BPI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E2G:~{N}-[[4-[2-(acetamidomethyl)phenyl]-5-methyl-1,2,4-triazol-3-yl]methyl]-2-azanyl-2-oxidanyl-ethanamide'>E2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bpi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bpi OCA], [https://pdbe.org/6bpi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bpi RCSB], [https://www.ebi.ac.uk/pdbsum/6bpi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bpi ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SETB1_HUMAN SETB1_HUMAN] Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.<ref>PMID:12869583</ref> <ref>PMID:14536086</ref> <ref>PMID:15327775</ref> <ref>PMID:17952062</ref>
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Authors: MADER, P., Mendoza-Sanchez, R., DONG, A., DOBROVETSKY, E., IQBAL, A., CORLESS, V., TEMPEL, W., LIEW, S.K., SMIL, D., DELA SENA, C.C., KENNEDY, S., DIAZ, D.B., SCHAPIRA, M., VEDADI, M., BROWN, P.J., Santhakumar, V., FRYE, S., Bountra, C., Edwards, A.M., YUDIN, A.K., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
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Description: Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Frye, S]]
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__TOC__
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[[Category: Diaz, D.B]]
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</StructureSection>
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[[Category: Arrowsmith, C.H]]
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[[Category: Homo sapiens]]
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[[Category: Santhakumar, V]]
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[[Category: Large Structures]]
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[[Category: Kennedy, S]]
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[[Category: Arrowsmith CH]]
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[[Category: Iqbal, A]]
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[[Category: BROWN PJ]]
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[[Category: Dong, A]]
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[[Category: Bountra C]]
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[[Category: Vedadi, M]]
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[[Category: CORLESS V]]
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[[Category: Brown, P.J]]
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[[Category: DELA SENA CC]]
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[[Category: Smil, D]]
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[[Category: DIAZ DB]]
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[[Category: Mendoza-Sanchez, R]]
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[[Category: DOBROVETSKY E]]
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[[Category: Corless, V]]
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[[Category: DONG A]]
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[[Category: Liew, S.K]]
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[[Category: Edwards AM]]
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[[Category: Yudin, A.K]]
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[[Category: FRYE S]]
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[[Category: Schapira, M]]
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[[Category: IQBAL A]]
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[[Category: Edwards, A.M]]
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[[Category: KENNEDY S]]
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[[Category: Dobrovetsky, E]]
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[[Category: LIEW SK]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: MADER P]]
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[[Category: Dela Sena, C.C]]
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[[Category: Mendoza-Sanchez R]]
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[[Category: Mader, P]]
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[[Category: SCHAPIRA M]]
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[[Category: Bountra, C]]
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[[Category: SMIL D]]
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[[Category: Tempel, W]]
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[[Category: Santhakumar V]]
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[[Category: TEMPEL W]]
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[[Category: VEDADI M]]
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[[Category: YUDIN AK]]

Current revision

Crystal structure of SETDB1 Tudor domain with aryl triazole fragment peptide conjugates

PDB ID 6bpi

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