2bpo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:52, 13 December 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2bpo.gif|left|200px]]
 
-
{{Structure
+
==Crystal structure of the yeast CPR triple mutant: D74G, Y75F, K78A.==
-
|PDB= 2bpo |SIZE=350|CAPTION= <scene name='initialview01'>2bpo</scene>, resolution 2.90&Aring;
+
<StructureSection load='2bpo' size='340' side='right'caption='[[2bpo]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
|SITE= <scene name='pdbsite=AC1:Nap+Binding+Site+For+Chain+B'>AC1</scene>
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
<table><tr><td colspan='2'>[[2bpo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BPO FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/NADPH--hemoprotein_reductase NADPH--hemoprotein reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.2.4 1.6.2.4] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpo OCA], [https://pdbe.org/2bpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bpo RCSB], [https://www.ebi.ac.uk/pdbsum/2bpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bpo ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2bpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bpo OCA], [http://www.ebi.ac.uk/pdbsum/2bpo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2bpo RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/NCPR_YEAST NCPR_YEAST] This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. Has NADPH-dependent ferrireductase activity on the plasma membrane.<ref>PMID:1730736</ref> <ref>PMID:9368374</ref> <ref>PMID:9468503</ref> <ref>PMID:11485306</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bp/2bpo_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bpo ConSurf].
 +
<div style="clear:both"></div>
-
'''CRYSTAL STRUCTURE OF THE YEAST CPR TRIPLE MUTANT: D74G, Y75F, K78A.'''
+
==See Also==
-
 
+
*[[NADPH-Cytochrome P450 Reductase|NADPH-Cytochrome P450 Reductase]]
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2BPO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BPO OCA].
+
__TOC__
-
[[Category: NADPH--hemoprotein reductase]]
+
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
-
[[Category: Single protein]]
+
[[Category: Kim Y]]
-
[[Category: Kim, Y.]]
+
[[Category: Podust LM]]
-
[[Category: Podust, L M.]]
+
[[Category: Waterman MR]]
-
[[Category: Waterman, M R.]]
+
[[Category: Yermalitskaya LV]]
-
[[Category: Yermalitskaya, L V.]]
+
-
[[Category: electron transfer]]
+
-
[[Category: fad]]
+
-
[[Category: fmn-binding]]
+
-
[[Category: nadp]]
+
-
[[Category: nadph-cytochrome p450 reductase,cpr,diflavin reductase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:09:49 2008''
+

Current revision

Crystal structure of the yeast CPR triple mutant: D74G, Y75F, K78A.

PDB ID 2bpo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2bpo"
Personal tools