6f1u
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==N terminal region of dynein tail domains in complex with dynactin filament and BICDR-1== | |
| + | <SX load='6f1u' size='340' side='right' viewer='molstar' caption='[[6f1u]], [[Resolution|resolution]] 3.40Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6f1u]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6F1U FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6f1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f1u OCA], [https://pdbe.org/6f1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6f1u RCSB], [https://www.ebi.ac.uk/pdbsum/6f1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6f1u ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACTZ_PIG ACTZ_PIG] Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules.<ref>PMID:25814576</ref> <ref>PMID:28602352</ref> <ref>PMID:29420470</ref> <ref>PMID:33734450</ref> <ref>PMID:36071160</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to distinct cargoes. Here we use electron microscopy and single-molecule studies to show that adaptors can recruit a second dynein to dynactin. Whereas BICD2 is biased towards recruiting a single dynein, the adaptors BICDR1 and HOOK3 predominantly recruit two dyneins. We find that the shift towards a double dynein complex increases both the force and speed of the microtubule motor. Our 3.5 A resolution cryo-electron microscopy reconstruction of a dynein tail-dynactin-BICDR1 complex reveals how dynactin can act as a scaffold to coordinate two dyneins side-by-side. Our work provides a structural basis for understanding how diverse adaptors recruit different numbers of dyneins and regulate the motile properties of the dynein-dynactin transport machine. | ||
| - | + | Cryo-EM shows how dynactin recruits two dyneins for faster movement.,Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP Nature. 2018 Feb 7;554(7691):202-206. doi: 10.1038/nature25462. PMID:29420470<ref>PMID:29420470</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6f1u" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: Carter | + | ==See Also== |
| - | [[Category: Elshenawy | + | *[[Actin-related protein 3D structures|Actin-related protein 3D structures]] |
| - | [[Category: | + | *[[Dynactin|Dynactin]] |
| - | [[Category: Morales-Rios | + | *[[Dynein 3D structures|Dynein 3D structures]] |
| - | [[Category: Yildiz | + | *[[F-actin capping protein|F-actin capping protein]] |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Carter AP]] | ||
| + | [[Category: Elshenawy MM]] | ||
| + | [[Category: Lau CK]] | ||
| + | [[Category: Morales-Rios E]] | ||
| + | [[Category: Motz C]] | ||
| + | [[Category: Urnavicius L]] | ||
| + | [[Category: Yildiz A]] | ||
Current revision
N terminal region of dynein tail domains in complex with dynactin filament and BICDR-1
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Categories: Homo sapiens | Large Structures | Mus musculus | Sus scrofa | Carter AP | Elshenawy MM | Lau CK | Morales-Rios E | Motz C | Urnavicius L | Yildiz A
