6f1v

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m (Protected "6f1v" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6f1v is ON HOLD
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==C terminal region of the dynein heavy chains in the dynein tail/dynactin/BICDR1 complex==
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<SX load='6f1v' size='340' side='right' viewer='molstar' caption='[[6f1v]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6f1v]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F1V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6F1V FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6f1t|6f1t]], [[6f1u|6f1u]]</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DYNC1H1, DHC1, DNCH1, DNCL, DNECL, DYHC, KIAA0325 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6f1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f1v OCA], [http://pdbe.org/6f1v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f1v RCSB], [http://www.ebi.ac.uk/pdbsum/6f1v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f1v ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Autosomal dominant childhood-onset proximal spinal muscular atrophy without contractures;Autosomal dominant non-syndromic intellectual disability;Autosomal dominant Charcot-Marie-Tooth disease type 2O. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/DYHC1_HUMAN DYHC1_HUMAN]] Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression (PubMed:27462074).<ref>PMID:27462074</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Dynein and its cofactor dynactin form a highly processive microtubule motor in the presence of an activating adaptor, such as BICD2. Different adaptors link dynein and dynactin to distinct cargoes. Here we use electron microscopy and single-molecule studies to show that adaptors can recruit a second dynein to dynactin. Whereas BICD2 is biased towards recruiting a single dynein, the adaptors BICDR1 and HOOK3 predominantly recruit two dyneins. We find that the shift towards a double dynein complex increases both the force and speed of the microtubule motor. Our 3.5 A resolution cryo-electron microscopy reconstruction of a dynein tail-dynactin-BICDR1 complex reveals how dynactin can act as a scaffold to coordinate two dyneins side-by-side. Our work provides a structural basis for understanding how diverse adaptors recruit different numbers of dyneins and regulate the motile properties of the dynein-dynactin transport machine.
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Authors: Urnavicius, L., Lau, C.K., Elshenawy, M.M., Morales-Rios, E., Motz, C., Yildiz, A., Carter, A.P.
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Cryo-EM shows how dynactin recruits two dyneins for faster movement.,Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP Nature. 2018 Feb 7;554(7691):202-206. doi: 10.1038/nature25462. PMID:29420470<ref>PMID:29420470</ref>
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Description: C terminal region of the dynein heavy chains in the dynein tail/dynactin/BICDR1 complex
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Lau, C.K]]
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<div class="pdbe-citations 6f1v" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</SX>
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[[Category: Human]]
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[[Category: Large Structures]]
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[[Category: Carter, A P]]
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[[Category: Elshenawy, M M]]
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[[Category: Lau, C K]]
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[[Category: Morales-Rios, E]]
[[Category: Motz, C]]
[[Category: Motz, C]]
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[[Category: Carter, A.P]]
 
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[[Category: Elshenawy, M.M]]
 
[[Category: Urnavicius, L]]
[[Category: Urnavicius, L]]
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[[Category: Morales-Rios, E]]
 
[[Category: Yildiz, A]]
[[Category: Yildiz, A]]
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[[Category: Complex]]
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[[Category: Cryo-em]]
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[[Category: Motor protein]]

Current revision

C terminal region of the dynein heavy chains in the dynein tail/dynactin/BICDR1 complex

6f1v, resolution 3.40Å

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