5y9l

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:46, 17 October 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==Human kallikrein 7 in complex with 1,3,6-trisubstituted 1,4-diazepane-7-one==
==Human kallikrein 7 in complex with 1,3,6-trisubstituted 1,4-diazepane-7-one==
-
<StructureSection load='5y9l' size='340' side='right' caption='[[5y9l]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
+
<StructureSection load='5y9l' size='340' side='right'caption='[[5y9l]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5y9l]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Y9L FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5y9l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y9L FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8R3:3-[2-[(3Z,6R)-6-[(5-chloranyl-2-methoxy-phenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxidanylidene-1,4-diazepan-1-yl]ethanoylamino]benzoic+acid'>8R3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Stratum_corneum_chymotryptic_enzyme Stratum corneum chymotryptic enzyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.117 3.4.21.117] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8R3:3-[2-[(3~{Z},6~{R})-6-[(5-chloranyl-2-methoxy-phenyl)methyl]-3-(dimethylhydrazinylidene)-7-oxidanylidene-1,4-diazepan-1-yl]ethanoylamino]benzoic+acid'>8R3</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5y9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9l OCA], [http://pdbe.org/5y9l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5y9l RCSB], [http://www.ebi.ac.uk/pdbsum/5y9l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9l ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y9l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9l OCA], [https://pdbe.org/5y9l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y9l RCSB], [https://www.ebi.ac.uk/pdbsum/5y9l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN]] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
+
[https://www.uniprot.org/uniprot/KLK7_HUMAN KLK7_HUMAN] May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5y9l" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5y9l" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Kallikrein 3D structures|Kallikrein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Stratum corneum chymotryptic enzyme]]
+
[[Category: Homo sapiens]]
-
[[Category: Sugawara, H]]
+
[[Category: Large Structures]]
-
[[Category: Hydrolase]]
+
[[Category: Sugawara H]]
-
[[Category: Inhibitor complex]]
+
-
[[Category: Protease]]
+

Current revision

Human kallikrein 7 in complex with 1,3,6-trisubstituted 1,4-diazepane-7-one

PDB ID 5y9l

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5y9l"
Personal tools