2brz

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[[Image:2brz.gif|left|200px]]
 
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{{Structure
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==SOLUTION NMR STRUCTURE OF THE SWEET PROTEIN BRAZZEIN, MINIMIZED AVERAGE STRUCTURE==
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|PDB= 2brz |SIZE=350|CAPTION= <scene name='initialview01'>2brz</scene>
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<StructureSection load='2brz' size='340' side='right'caption='[[2brz]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene>
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<table><tr><td colspan='2'>[[2brz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pentadiplandra_brazzeana Pentadiplandra brazzeana]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BRZ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2brz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2brz OCA], [https://pdbe.org/2brz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2brz RCSB], [https://www.ebi.ac.uk/pdbsum/2brz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2brz ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2brz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2brz OCA], [http://www.ebi.ac.uk/pdbsum/2brz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2brz RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/DEF_PENBA DEF_PENBA] Taste-modifying protein; sweet-tasting. It is 2000 sweeter than sucrose on a molar basis.<ref>PMID:15118082</ref> Has a pH-specific antimicrobial activity against bacteria (B.subtilis, E.coli and S.aureus) and the fungus C.albicans.<ref>PMID:15118082</ref>
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<div style="background-color:#fffaf0;">
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'''SOLUTION NMR STRUCTURE OF THE SWEET PROTEIN BRAZZEIN, MINIMIZED AVERAGE STRUCTURE'''
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== Publication Abstract from PubMed ==
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==Overview==
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The fruit of Pentadiplandra brazzeana Baillon contains a small, sweet-tasting protein named brazzein. The structure of brazzein in solution was determined by proton nuclear magnetic resonance spectroscopy at pH 5.2 and 22 degrees C. The brazzein fold, which contains one alpha-helix and three strands of antiparallel beta-sheet, does not resemble that of either of the other two sweet-tasting proteins with known structures, monellin and thaumatin. Instead, the structure of brazzein resembles those of plant gamma-thionins and defensins and arthropod toxins. Sequence comparisons predict that members of a newly-identified family of serine proteinase inhibitors share the brazzein fold.
The fruit of Pentadiplandra brazzeana Baillon contains a small, sweet-tasting protein named brazzein. The structure of brazzein in solution was determined by proton nuclear magnetic resonance spectroscopy at pH 5.2 and 22 degrees C. The brazzein fold, which contains one alpha-helix and three strands of antiparallel beta-sheet, does not resemble that of either of the other two sweet-tasting proteins with known structures, monellin and thaumatin. Instead, the structure of brazzein resembles those of plant gamma-thionins and defensins and arthropod toxins. Sequence comparisons predict that members of a newly-identified family of serine proteinase inhibitors share the brazzein fold.
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==About this Structure==
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Solution structure of the thermostable sweet-tasting protein brazzein.,Caldwell JE, Abildgaard F, Dzakula Z, Ming D, Hellekant G, Markley JL Nat Struct Biol. 1998 Jun;5(6):427-31. PMID:9628478<ref>PMID:9628478</ref>
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2BRZ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pentadiplandra_brazzeana Pentadiplandra brazzeana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BRZ OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of the thermostable sweet-tasting protein brazzein., Caldwell JE, Abildgaard F, Dzakula Z, Ming D, Hellekant G, Markley JL, Nat Struct Biol. 1998 Jun;5(6):427-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9628478 9628478]
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</div>
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<div class="pdbe-citations 2brz" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pentadiplandra brazzeana]]
[[Category: Pentadiplandra brazzeana]]
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[[Category: Single protein]]
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[[Category: Abildgaard F]]
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[[Category: Abildgaard, F.]]
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[[Category: Caldwell JE]]
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[[Category: Caldwell, J E.]]
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[[Category: Dzakula Z]]
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[[Category: Dzakula, Z.]]
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[[Category: Hellekant G]]
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[[Category: Hellekant, G.]]
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[[Category: Markley JL]]
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[[Category: Markley, J L.]]
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[[Category: Ming D]]
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[[Category: Ming, D.]]
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[[Category: cysteine-stabilized alpha-beta]]
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[[Category: sweet protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:10:51 2008''
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Current revision

SOLUTION NMR STRUCTURE OF THE SWEET PROTEIN BRAZZEIN, MINIMIZED AVERAGE STRUCTURE

PDB ID 2brz

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