2buj

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[[Image:2buj.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine==
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|PDB= 2buj |SIZE=350|CAPTION= <scene name='initialview01'>2buj</scene>, resolution 2.60&Aring;
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<StructureSection load='2buj' size='340' side='right'caption='[[2buj]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Stu+Binding+Site+For+Chain+B'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene>
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<table><tr><td colspan='2'>[[2buj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BUJ FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=STU:STAUROSPORINE'>STU</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2buj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2buj OCA], [https://pdbe.org/2buj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2buj RCSB], [https://www.ebi.ac.uk/pdbsum/2buj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2buj ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2buj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2buj OCA], [http://www.ebi.ac.uk/pdbsum/2buj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2buj RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/STK16_HUMAN STK16_HUMAN] Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.<ref>PMID:10364453</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bu/2buj_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2buj ConSurf].
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<div style="clear:both"></div>
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'''CRYSTAL STRUCTURE OF THE HUMAN SERINE-THREONINE KINASE 16 IN COMPLEX WITH STAUROSPORINE'''
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==See Also==
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*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2BUJ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BUJ OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Amos A]]
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[[Category: Amos, A.]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Ball LJ]]
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[[Category: Ball, L J.]]
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[[Category: Bullock A]]
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[[Category: Bullock, A.]]
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[[Category: Debreczeni JE]]
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[[Category: Debreczeni, J E.]]
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[[Category: Edwards A]]
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[[Category: Delft, F Von.]]
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[[Category: Eswaran J]]
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[[Category: Edwards, A.]]
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[[Category: Fedorov O]]
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[[Category: Eswaran, J.]]
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[[Category: Filippakopoulos P]]
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[[Category: Fedorov, O.]]
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[[Category: Kavanagh K]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Knapp S]]
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[[Category: Kavanagh, K.]]
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[[Category: Sobott F]]
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[[Category: Knapp, S.]]
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[[Category: Sundstrom M]]
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[[Category: Sobott, F.]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M.]]
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[[Category: atp-binding]]
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[[Category: kinase]]
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[[Category: lipoprotein]]
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[[Category: myristate]]
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[[Category: palmitate]]
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[[Category: phosphorylation]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:11:59 2008''
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Current revision

Crystal structure of the human Serine-threonine Kinase 16 in complex with staurosporine

PDB ID 2buj

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