3opd

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==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a benzamide derivative==
==Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a benzamide derivative==
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<StructureSection load='3opd' size='340' side='right' caption='[[3opd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='3opd' size='340' side='right'caption='[[3opd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3opd]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OPD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3opd]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OPD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OPD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HIE:4-[6,6-DIMETHYL-4-OXO-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOL-1-YL]-2-[(CIS-4-HYDROXYCYCLOHEXYL)AMINO]BENZAMIDE'>HIE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3o6o|3o6o]], [[3omu|3omu]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E0G:4-[6,6-dimethyl-4-oxidanylidene-3-(trifluoromethyl)-5,7-dihydroindazol-1-yl]-2-[(4-oxidanylcyclohexyl)amino]benzamide'>E0G</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HSP83, Tb10.26.1080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5702 TRYBB])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3opd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opd OCA], [https://pdbe.org/3opd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3opd RCSB], [https://www.ebi.ac.uk/pdbsum/3opd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3opd ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3opd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opd OCA], [http://pdbe.org/3opd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3opd RCSB], [http://www.ebi.ac.uk/pdbsum/3opd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3opd ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HSP83_TRYBB HSP83_TRYBB]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
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[https://www.uniprot.org/uniprot/HSP83_TRYBB HSP83_TRYBB] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3opd" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3opd" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Trybb]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Trypanosoma brucei brucei]]
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[[Category: Bochkarev, A]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra, C]]
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[[Category: Bochkarev A]]
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[[Category: Chamberlain, K]]
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[[Category: Bountra C]]
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[[Category: Cossar, D]]
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[[Category: Chamberlain K]]
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[[Category: Edwards, A M]]
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[[Category: Cossar D]]
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[[Category: Fairlamb, A H]]
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[[Category: Edwards AM]]
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[[Category: Ferguson, M A.J]]
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[[Category: Fairlamb AH]]
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[[Category: Hills, T]]
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[[Category: Ferguson MAJ]]
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[[Category: Hui, R]]
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[[Category: Hills T]]
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[[Category: Hutchinson, A]]
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[[Category: Hui R]]
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[[Category: Kozieradzki, I]]
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[[Category: Hutchinson A]]
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[[Category: Li, Y]]
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[[Category: Kozieradzki I]]
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[[Category: MacKenzie, C]]
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[[Category: Li Y]]
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[[Category: Pizarro, J C]]
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[[Category: MacKenzie C]]
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[[Category: Structural genomic]]
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[[Category: Pizarro JC]]
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[[Category: Sullivan, H]]
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[[Category: Sullivan H]]
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[[Category: Weadge, J]]
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[[Category: Weadge J]]
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[[Category: Weigelt, J]]
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[[Category: Weigelt J]]
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[[Category: Wernimont, A K]]
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[[Category: Wernimont AK]]
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[[Category: Wyatt, P G]]
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[[Category: Wyatt PG]]
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[[Category: Atp binding]]
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[[Category: Chaperone]]
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[[Category: Sgc]]
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Current revision

Crystal Structure of the N-terminal domain of an HSP90 from Trypanosoma Brucei, Tb10.26.1080 in the presence of a benzamide derivative

PDB ID 3opd

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