This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1bq2

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (05:40, 9 August 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==E. COLI THYMIDYLATE SYNTHASE MUTANT N177A==
==E. COLI THYMIDYLATE SYNTHASE MUTANT N177A==
-
<StructureSection load='1bq2' size='340' side='right' caption='[[1bq2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
+
<StructureSection load='1bq2' size='340' side='right'caption='[[1bq2]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1bq2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQ2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BQ2 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1bq2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BQ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BQ2 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">THYA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1bq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bq2 OCA], [https://pdbe.org/1bq2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1bq2 RCSB], [https://www.ebi.ac.uk/pdbsum/1bq2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1bq2 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bq2 OCA], [http://pdbe.org/1bq2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1bq2 RCSB], [http://www.ebi.ac.uk/pdbsum/1bq2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1bq2 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI]] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
+
[https://www.uniprot.org/uniprot/TYSY_ECOLI TYSY_ECOLI] Provides the sole de novo source of dTMP for DNA biosynthesis. This protein also binds to its mRNA thus repressing its own translation.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
-
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/1bq2_consurf.spt"</scriptWhenChecked>
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bq/1bq2_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
Line 30: Line 29:
</div>
</div>
<div class="pdbe-citations 1bq2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1bq2" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Thymidylate synthase 3D structures|Thymidylate synthase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Bacillus coli migula 1895]]
+
[[Category: Escherichia coli]]
-
[[Category: Thymidylate synthase]]
+
[[Category: Large Structures]]
-
[[Category: Finer-Moore, J S]]
+
[[Category: Finer-Moore JS]]
-
[[Category: Reyes, C L]]
+
[[Category: Reyes CL]]
-
[[Category: Rutenber, E E]]
+
[[Category: Rutenber EE]]
-
[[Category: Sage, C R]]
+
[[Category: Sage CR]]
-
[[Category: Stroud, R M]]
+
[[Category: Stroud RM]]
-
[[Category: Methyltransferase]]
+
-
[[Category: Substrate module]]
+
-
[[Category: Transferase]]
+

Current revision

E. COLI THYMIDYLATE SYNTHASE MUTANT N177A

PDB ID 1bq2

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bq2"
Personal tools