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2c0c

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[[Image:2c0c.gif|left|200px]]
 
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{{Structure
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==Structure of the MGC45594 gene product==
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|PDB= 2c0c |SIZE=350|CAPTION= <scene name='initialview01'>2c0c</scene>, resolution 1.45&Aring;
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<StructureSection load='2c0c' size='340' side='right'caption='[[2c0c]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Nap+Binding+Site+For+Chain+B'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>
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<table><tr><td colspan='2'>[[2c0c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0C FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0c OCA], [https://pdbe.org/2c0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0c RCSB], [https://www.ebi.ac.uk/pdbsum/2c0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0c ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0c OCA], [http://www.ebi.ac.uk/pdbsum/2c0c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c0c RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PTGR3_HUMAN PTGR3_HUMAN] Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation.[UniProtKB:Q8BGC4]
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== Evolutionary Conservation ==
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'''STRUCTURE OF THE MGC45594 GENE PRODUCT'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c0/2c0c_consurf.spt"</scriptWhenChecked>
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2C0C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0C OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c0c ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Guo K]]
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[[Category: Guo, K.]]
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[[Category: Oppermann U]]
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[[Category: Oppermann, U.]]
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[[Category: Shafqat N]]
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[[Category: Shafqat, N.]]
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[[Category: Smee C]]
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[[Category: Smee, C.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: medium-chain dehydrogenase/reductase]]
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[[Category: quinone oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:14:29 2008''
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Current revision

Structure of the MGC45594 gene product

PDB ID 2c0c

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