6br3
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6br3 is ON HOLD Authors: Skene, R.J., Hoffman, I. Description: Structure of RORgt in complex with a novel inverse agonist TAK-828. [[Category: Unre...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of RORgt in complex with a novel inverse agonist TAK-828.== | |
| - | + | <StructureSection load='6br3' size='340' side='right'caption='[[6br3]], [[Resolution|resolution]] 3.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6br3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BR3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BR3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E3V:{cis-3-[(5R)-5-[(7-fluoro-1,1-dimethyl-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridine-6(5H)-carbonyl]cyclobutyl}acetic+acid'>E3V</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr> |
| - | [[Category: Hoffman | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6br3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6br3 OCA], [https://pdbe.org/6br3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6br3 RCSB], [https://www.ebi.ac.uk/pdbsum/6br3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6br3 ProSAT]</span></td></tr> |
| - | [[Category: Skene | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hoffman I]] | ||
| + | [[Category: Skene RJ]] | ||
Current revision
Structure of RORgt in complex with a novel inverse agonist TAK-828.
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