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5m41

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Crystal structure of nigritoxine

Structural highlights

5m41 is a 1 chain structure with sequence from Vibrio nigripulchritudo. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

The Tetraconata (Pancrustacea) concept proposes that insects are more closely related to aquatic crustaceans than to terrestrial centipedes or millipedes. The question therefore arises whether insects have kept crustacean-specific genetic traits that could be targeted by specific toxins. Here we show that a toxin (nigritoxin), originally identified in a bacterial pathogen of shrimp, is lethal for organisms within the Tetraconata and non-toxic to other animals. X-ray crystallography reveals that nigritoxin possesses a new protein fold of the alpha/beta type. The nigritoxin N-terminal domain is essential for cellular translocation and likely encodes specificity for Tetraconata. Once internalized by eukaryotic cells, nigritoxin induces apoptotic cell death through structural features that are localized in the C-terminal domain of the protein. We propose that nigritoxin will be an effective means to identify a Tetraconata evolutionarily conserved pathway and speculate that nigritoxin holds promise as an insecticidal protein.

Nigritoxin is a bacterial toxin for crustaceans and insects.,Labreuche Y, Chenivesse S, Jeudy A, Le Panse S, Boulo V, Ansquer D, Pages S, Givaudan A, Czjzek M, Le Roux F Nat Commun. 2017 Nov 1;8(1):1248. doi: 10.1038/s41467-017-01445-z. PMID:29093459^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Labreuche Y, Chenivesse S, Jeudy A, Le Panse S, Boulo V, Ansquer D, Pages S, Givaudan A, Czjzek M, Le Roux F. Nigritoxin is a bacterial toxin for crustaceans and insects. Nat Commun. 2017 Nov 1;8(1):1248. doi: 10.1038/s41467-017-01445-z. PMID:29093459 doi:http://dx.doi.org/10.1038/s41467-017-01445-z

1 Structural highlights
2 Publication Abstract from PubMed
3 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5m41"

@@ Line 1: / Line 1: @@
 ==Crystal structure of nigritoxine==
-<StructureSection load='5m41' size='340' side='right' caption='[[5m41]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
+<StructureSection load='5m41' size='340' side='right'caption='[[5m41]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[5m41]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M41 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5M41 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[5m41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_nigripulchritudo Vibrio nigripulchritudo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M41 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5m41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m41 OCA], [http://pdbe.org/5m41 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5m41 RCSB], [http://www.ebi.ac.uk/pdbsum/5m41 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5m41 ProSAT]</span></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m41 OCA], [https://pdbe.org/5m41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m41 RCSB], [https://www.ebi.ac.uk/pdbsum/5m41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m41 ProSAT]</span></td></tr>
 </table>
 <div style="background-color:#fffaf0;">
@@ Line 20: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Czjzek, M]]
+[[Category: Large Structures]]
-[[Category: Jeudy, A]]
+[[Category: Vibrio nigripulchritudo]]
-[[Category: Labreuche, L]]
+[[Category: Czjzek M]]
-[[Category: Roux, F Le]]
+[[Category: Jeudy A]]
-[[Category: Arthropod]]
+[[Category: Labreuche L]]
-[[Category: New fold]]
+[[Category: Le Roux F]]
-[[Category: Toxin]]

5m41

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Current revision

Crystal structure of nigritoxine

Structural highlights

Publication Abstract from PubMed

References

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