2c2w

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[[Image:2c2w.gif|left|200px]]
 
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{{Structure
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==The fluorinase from Streptomyces cattleya is also a chlorinase. Structure of 5'-chloro-5'-deoxyadenosine crystallised in the fluorinase.==
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|PDB= 2c2w |SIZE=350|CAPTION= <scene name='initialview01'>2c2w</scene>, resolution 2.00&Aring;
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<StructureSection load='2c2w' size='340' side='right'caption='[[2c2w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Cl+Binding+Site+For+Chain+B'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=5CD:5&#39;-CHLORO-5&#39;-DEOXYADENOSINE'>5CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
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<table><tr><td colspan='2'>[[2c2w]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C2W FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosyl-fluoride_synthase Adenosyl-fluoride synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.63 2.5.1.63] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5CD:5-CHLORO-5-DEOXYADENOSINE'>5CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2w OCA], [https://pdbe.org/2c2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c2w RCSB], [https://www.ebi.ac.uk/pdbsum/2c2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c2w ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c2w OCA], [http://www.ebi.ac.uk/pdbsum/2c2w PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c2w RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/FLA_STRCT FLA_STRCT] Involved in the biosynthesis of fluorometabolites. Catalyzes the formation of a C-F bond by combining S-adenosyl-L-methionine (SAM) and fluoride to generate 5'-fluoro-5'-deoxyadenosine (5'-FDA) and L-methionine. It can also use 2'-deoxyadenosine in place of adenosine as substrate.<ref>PMID:12860396</ref> <ref>PMID:14765200</ref> <ref>PMID:16370017</ref> <ref>PMID:16604208</ref> <ref>PMID:16720268</ref> <ref>PMID:17985882</ref>
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== Evolutionary Conservation ==
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'''THE FLUORINASE FROM STREPTOMYCES CATTLEYA IS ALSO A CHLORINASE. STRUCTURE OF 5'-CHLORO-5'-DEOXYADENOSINE CRYSTALLISED IN THE FLUORINASE.'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c2/2c2w_consurf.spt"</scriptWhenChecked>
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2C2W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C2W OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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The fluorinase from Streptomyces cattleya is also a chlorinase., Deng H, Cobb SL, McEwan AR, McGlinchey RP, Naismith JH, O'Hagan D, Robinson DA, Spencer JB, Angew Chem Int Ed Engl. 2006 Jan 23;45(5):759-62. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16370017 16370017]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c2w ConSurf].
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[[Category: Adenosyl-fluoride synthase]]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces cattleya]]
[[Category: Streptomyces cattleya]]
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[[Category: Hagan, D O.]]
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[[Category: McEwan AR]]
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[[Category: Mcewan, A R.]]
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[[Category: Naismith JH]]
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[[Category: Naismith, J H.]]
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[[Category: O'Hagan D]]
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[[Category: 5'-chloro-5'-deoxyadenosine]]
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[[Category: bacterial chlorinating enzyme]]
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[[Category: bacterial fluorinating enzyme]]
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[[Category: chlorinase]]
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[[Category: fla]]
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[[Category: fluorinase]]
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[[Category: streptomyces cattleya]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:15:33 2008''
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Current revision

The fluorinase from Streptomyces cattleya is also a chlorinase. Structure of 5'-chloro-5'-deoxyadenosine crystallised in the fluorinase.

PDB ID 2c2w

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