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5wn8

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==Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1==
==Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1==
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<StructureSection load='5wn8' size='340' side='right' caption='[[5wn8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='5wn8' size='340' side='right'caption='[[5wn8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wn8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WN8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WN8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wn8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WN8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BBJ:N-(3-bromo-4-fluorophenyl)-N-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide'>BBJ</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wmu|5wmu]], [[5wmv|5wmv]], [[5wmw|5wmw]], [[5wmx|5wmx]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BBJ:N-(3-bromo-4-fluorophenyl)-N-hydroxy-4-{[2-(sulfamoylamino)ethyl]amino}-1,2,5-oxadiazole-3-carboximidamide'>BBJ</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indoleamine_2,3-dioxygenase Indoleamine 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.52 1.13.11.52] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wn8 OCA], [https://pdbe.org/5wn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wn8 RCSB], [https://www.ebi.ac.uk/pdbsum/5wn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wn8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wn8 OCA], [http://pdbe.org/5wn8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wn8 RCSB], [http://www.ebi.ac.uk/pdbsum/5wn8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wn8 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN]] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
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[https://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5wn8" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5wn8" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Indoleamine 2,3-dioxygenase]]
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[[Category: Homo sapiens]]
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[[Category: Batabyal, D]]
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[[Category: Large Structures]]
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[[Category: Bonanno, J B]]
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[[Category: Batabyal D]]
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[[Category: Karkashon, S]]
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[[Category: Bonanno JB]]
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[[Category: Lewis-Ballester, A]]
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[[Category: Karkashon S]]
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[[Category: Pham, K N]]
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[[Category: Lewis-Ballester A]]
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[[Category: Poulos, T L]]
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[[Category: Pham KN]]
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[[Category: Yeh, S R]]
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[[Category: Poulos TL]]
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[[Category: 3-dioxygenase 1 tryptophan heme inhibitor epacadostat incb024360]]
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[[Category: Yeh SR]]
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[[Category: Indoleamine 2]]
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[[Category: Oxidoreductase]]
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Current revision

Structural Insights into Substrate and Inhibitor Binding Sites in Human Indoleamine 2,3-Dioxygenase 1

PDB ID 5wn8

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