5xjz

<StructureSection load='5xjz' size='340' side='right' caption='[[5xjz]], [[Resolution|resolution]] 0.98&Aring;' scene=''>

<table><tr><td colspan='2'>[[5xjz]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XJZ FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AG:SILVER+ION'>AG</scene>, <scene name='pdbligand=SPM:SPERMINE'>SPM</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xjz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xjz OCA], [http://pdbe.org/5xjz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xjz RCSB], [http://www.ebi.ac.uk/pdbsum/5xjz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xjz ProSAT]</span></td></tr>

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== Publication Abstract from PubMed ==

Metal-mediated base pairs have been extensively utilized in many research fields, including genetic-code extension, novel therapeutics development, and nanodevice design. Compared to other cations, Ag(I) is more flexible in pairing with natural base pairs. Herein, we present a DNA structure containing two C-Ag(I) -C pairs and the first reported G-Ag(I) -G pair in a short 8mer DNA strand. This structure not only provides detailed insight into these Ag(I) -mediated base-pairing patterns in DNA, but also represents the first nonhelical DNA structure driven by heavy-metal ions, thus further contributing to the structural diversity of DNA. This unique complex structure is highly sequence-dependent, thus implying functional potentials as a new DNA aptamer that can bind and recognize silver ions. These results not only advance our understanding of the interactions between Ag(I) and nucleobases, but also provide a unique structural component for the rational design of new DNA nanodevices.

A DNA Structure Containing Ag(I) -Mediated G:G and C:C Base Pairs.,Liu H, Shen F, Haruehanroengra P, Yao Q, Cheng Y, Chen Y, Yang C, Zhang J, Wu B, Luo Q, Cui R, Li J, Ma J, Sheng J, Gan J Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9430-9434. doi: 10.1002/anie.201704891., Epub 2017 Jul 7. PMID:28635152<ref>PMID:28635152</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 5xjz" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Gan, J H]]

[[Category: Liu, H H]]

[[Category: Ag]]

[[Category: Base pair]]

[[Category: Dna]]