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5j1y

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Current revision (10:42, 6 September 2023) (edit) (undo)
 
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==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-(pyrrolidin-1-yl)-3-(tetrahydrofuran-3-yl)propan-1-one at 1.81A resolution==
==Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-(pyrrolidin-1-yl)-3-(tetrahydrofuran-3-yl)propan-1-one at 1.81A resolution==
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<StructureSection load='5j1y' size='340' side='right' caption='[[5j1y]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
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<StructureSection load='5j1y' size='340' side='right'caption='[[5j1y]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j1y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1Y OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J1Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j1y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J1Y FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P87:3-[(3S)-OXOLAN-3-YL]-1-(PYRROLIDIN-1-YL)PROPAN-1-ONE'>P87</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ethR_2, ethR, ethR_1, AFL40_4013, BN1213_00375, BN1303_02839, ERS007657_00006, ERS007665_03402, ERS007670_00101, ERS007672_00126, ERS007679_01009, ERS007681_01169, ERS007688_00760, ERS007703_00420, ERS007722_01164, ERS007741_02569, ERS013447_02283, ERS013471_02551, ERS023446_02032, ERS024213_01441, ERS024276_01130, ERS027644_00684, ERS027646_02322, ERS027654_00374, ERS027656_00876, ERS031537_01716, ERS075357_02728, ERS075361_00362, ERS075387_01097, ERS124361_02860, IQ38_20160, IQ40_19545, IQ45_19480, IQ47_19420, IU13_19735, IU16_19625 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P87:3-[(3S)-OXOLAN-3-YL]-1-(PYRROLIDIN-1-YL)PROPAN-1-ONE'>P87</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j1y OCA], [http://pdbe.org/5j1y PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j1y RCSB], [http://www.ebi.ac.uk/pdbsum/5j1y PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j1y ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j1y OCA], [https://pdbe.org/5j1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j1y RCSB], [https://www.ebi.ac.uk/pdbsum/5j1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j1y ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5j1y" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5j1y" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abell, C]]
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[[Category: Large Structures]]
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[[Category: Blaszczyk, M]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Blundell, T L]]
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[[Category: Abell C]]
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[[Category: Nikiforov, P O]]
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[[Category: Blaszczyk M]]
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[[Category: Surade, S]]
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[[Category: Blundell TL]]
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[[Category: Boosting effect]]
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[[Category: Nikiforov PO]]
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[[Category: Ethr]]
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[[Category: Surade S]]
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[[Category: Represor]]
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[[Category: Transcription]]
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Current revision

Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-(pyrrolidin-1-yl)-3-(tetrahydrofuran-3-yl)propan-1-one at 1.81A resolution

PDB ID 5j1y

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