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5nes

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Current revision (12:51, 15 November 2023) (edit) (undo)
 
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==Discovery, crystal structures and atomic force microscopy study of thioether ligated D,L-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa==
==Discovery, crystal structures and atomic force microscopy study of thioether ligated D,L-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa==
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<StructureSection load='5nes' size='340' side='right' caption='[[5nes]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
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<StructureSection load='5nes' size='340' side='right'caption='[[5nes]], [[Resolution|resolution]] 1.61&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nes]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NES OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NES FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nes]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NES OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NES FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=8VH:1,3-dimethylbenzene'>8VH</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZDC:3,7-ANHYDRO-2,8-DIDEOXY-L-GLYCERO-D-GLUCO-OCTONIC+ACID'>ZDC</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.606&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DLY:D-LYSINE'>DLY</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8VH:1,3-dimethylbenzene'>8VH</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DCY:D-CYSTEINE'>DCY</scene>, <scene name='pdbligand=DLY:D-LYSINE'>DLY</scene>, <scene name='pdbligand=DTR:D-TRYPTOPHAN'>DTR</scene>, <scene name='pdbligand=ZDC:3,7-ANHYDRO-2,8-DIDEOXY-L-GLYCERO-D-GLUCO-OCTONIC+ACID'>ZDC</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lecB, PAERUG_E15_London_28_01_14_00983, PAERUG_P32_London_17_VIM_2_10_11_00423, PAMH19_1713 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nes OCA], [https://pdbe.org/5nes PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nes RCSB], [https://www.ebi.ac.uk/pdbsum/5nes PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nes ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nes FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nes OCA], [http://pdbe.org/5nes PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nes RCSB], [http://www.ebi.ac.uk/pdbsum/5nes PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nes ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9HYN5_PSEAE Q9HYN5_PSEAE]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bonaventura, I Di]]
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[[Category: Large Structures]]
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[[Category: Darbre, T]]
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[[Category: Delden, C van]]
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[[Category: Fu, Y]]
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[[Category: He, R]]
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[[Category: Hong, W]]
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[[Category: Koehler, T]]
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[[Category: Luscher, A]]
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[[Category: Reymond, J L]]
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[[Category: Stocker, A]]
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[[Category: Visini, R]]
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[[Category: Antimicrobial]]
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[[Category: Cyclic peptide]]
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[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Sugar binding protein]]
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[[Category: Synthetic construct]]
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[[Category: Darbre T]]
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[[Category: Di Bonaventura I]]
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[[Category: Fu Y]]
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[[Category: He R]]
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[[Category: Hong W]]
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[[Category: Koehler T]]
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[[Category: Luscher A]]
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[[Category: Reymond J-L]]
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[[Category: Stocker A]]
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[[Category: Visini R]]
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[[Category: Van Delden C]]

Current revision

Discovery, crystal structures and atomic force microscopy study of thioether ligated D,L-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa

PDB ID 5nes

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