6b7y
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Cryo-EM structure of human insulin degrading enzyme== | ==Cryo-EM structure of human insulin degrading enzyme== | ||
| - | < | + | <SX load='6b7y' size='340' side='right' viewer='molstar' caption='[[6b7y]], [[Resolution|resolution]] 6.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6b7y]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6b7y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B7Y FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b7y OCA], [https://pdbe.org/6b7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b7y RCSB], [https://www.ebi.ac.uk/pdbsum/6b7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b7y ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
| - | </ | + | </SX> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Bailey | + | [[Category: Bailey LJ]] |
| - | [[Category: Carragher | + | [[Category: Carragher B]] |
| - | [[Category: Kossiakoff | + | [[Category: Kossiakoff AA]] |
| - | [[Category: Liang | + | [[Category: Liang WG]] |
| - | [[Category: Potter | + | [[Category: Potter SC]] |
| - | [[Category: Tan | + | [[Category: Tan YZ]] |
| - | [[Category: Tang | + | [[Category: Tang WJ]] |
| - | [[Category: Wei | + | [[Category: Wei H]] |
| - | [[Category: Zhang | + | [[Category: Zhang Z]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Cryo-EM structure of human insulin degrading enzyme
| |||||||||
Categories: Homo sapiens | Large Structures | Bailey LJ | Carragher B | Kossiakoff AA | Liang WG | Potter SC | Tan YZ | Tang WJ | Wei H | Zhang Z
