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5qd7
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of BACE complex with BMC014== | |
| - | + | <StructureSection load='5qd7' size='340' side='right'caption='[[5qd7]], [[Resolution|resolution]] 2.12Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5qd7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QD7 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0BI:(4S)-4-[(1R)-1-HYDROXY-2-({1-[3-(1-METHYLETHYL)PHENYL]CYCLOPROPYL}AMINO)ETHYL]-19-(METHOXYMETHYL)-11-OXA-3,16-DIAZATRICYCLO[15.3.1.1~6,10~]DOCOSA-1(21),6(22),7,9,17,19-HEXAEN-2-ONE'>0BI</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qd7 OCA], [https://pdbe.org/5qd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qd7 RCSB], [https://www.ebi.ac.uk/pdbsum/5qd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qd7 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Burley SK]] | ||
| + | [[Category: Rondeau JM]] | ||
| + | [[Category: Shao C]] | ||
| + | [[Category: Yang H]] | ||
Current revision
Crystal structure of BACE complex with BMC014
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