2c95

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[[Image:2c95.jpg|left|200px]]
 
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{{Structure
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==Structure of adenylate kinase 1 in complex with P1,P4-di(adenosine) tetraphosphate==
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|PDB= 2c95 |SIZE=350|CAPTION= <scene name='initialview01'>2c95</scene>, resolution 1.71&Aring;
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<StructureSection load='2c95' size='340' side='right'caption='[[2c95]], [[Resolution|resolution]] 1.71&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Mli+Binding+Site+For+Chain+B'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=B4P:BIS(ADENOSINE)-5&#39;-TETRAPHOSPHATE'>B4P</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>
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<table><tr><td colspan='2'>[[2c95]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C95 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C95 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.71&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B4P:BIS(ADENOSINE)-5-TETRAPHOSPHATE'>B4P</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c95 OCA], [https://pdbe.org/2c95 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c95 RCSB], [https://www.ebi.ac.uk/pdbsum/2c95 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c95 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2c95 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c95 OCA], [http://www.ebi.ac.uk/pdbsum/2c95 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2c95 RCSB]</span>
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== Disease ==
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}}
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[https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:[https://omim.org/entry/612631 612631].<ref>PMID:2542324</ref> <ref>PMID:9432020</ref> <ref>PMID:12649162</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/KAD1_HUMAN KAD1_HUMAN] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c9/2c95_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2c95 ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF ADENYLATE KINASE 1 IN COMPLEX WITH P1,P4-DI (ADENOSINE)TETRAPHOSPHATE'''
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==See Also==
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*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2C95 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C95 OCA].
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__TOC__
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[[Category: Adenylate kinase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Delft, F Von.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Filippakopoulos P]]
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[[Category: Filippakopoulos, P.]]
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[[Category: Jansson A]]
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[[Category: Jansson, A.]]
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[[Category: Knapp S]]
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[[Category: Knapp, S.]]
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[[Category: Longman E]]
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[[Category: Longman, E.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Von Delft F]]
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[[Category: adenylate kinase]]
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[[Category: ap4a]]
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[[Category: atp-binding]]
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[[Category: kinase]]
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[[Category: nucleotide kinase]]
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[[Category: transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:18:12 2008''
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Current revision

Structure of adenylate kinase 1 in complex with P1,P4-di(adenosine) tetraphosphate

PDB ID 2c95

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OCA

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