5mn2

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==Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.==
==Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.==
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<StructureSection load='5mn2' size='340' side='right' caption='[[5mn2]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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<StructureSection load='5mn2' size='340' side='right'caption='[[5mn2]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mn2]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MN2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mn2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MN2 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mn2 OCA], [http://pdbe.org/5mn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mn2 RCSB], [http://www.ebi.ac.uk/pdbsum/5mn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mn2 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mn2 OCA], [https://pdbe.org/5mn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mn2 RCSB], [https://www.ebi.ac.uk/pdbsum/5mn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mn2 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23006327</ref> <ref>PMID:8608639</ref> <ref>PMID:8609432</ref> <ref>PMID:8874200</ref>
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[https://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN] The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23006327</ref> <ref>PMID:8608639</ref> <ref>PMID:8609432</ref> <ref>PMID:8874200</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN]] Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.<ref>PMID:21768335</ref> <ref>PMID:22023369</ref>
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[https://www.uniprot.org/uniprot/FCG3A_HUMAN FCG3A_HUMAN] Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.<ref>PMID:21768335</ref> <ref>PMID:22023369</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Baxter, E W]]
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[[Category: Homo sapiens]]
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[[Category: Goldman, A]]
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[[Category: Large Structures]]
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[[Category: Harris, S A]]
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[[Category: Synthetic construct]]
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[[Category: McPherson, M J]]
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[[Category: Baxter EW]]
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[[Category: Morgan, A W]]
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[[Category: Goldman A]]
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[[Category: Nettleship, J E]]
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[[Category: Harris SA]]
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[[Category: Owen, R L]]
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[[Category: McPherson MJ]]
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[[Category: Owens, R J]]
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[[Category: Morgan AW]]
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[[Category: Robinson, J I]]
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[[Category: Nettleship JE]]
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[[Category: Thomsen, M]]
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[[Category: Owen RL]]
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[[Category: Tiede, C]]
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[[Category: Owens RJ]]
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[[Category: Tomlinson, D C]]
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[[Category: Robinson JI]]
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[[Category: Waterhouse, M P]]
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[[Category: Thomsen M]]
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[[Category: Fc gamma receptor iiia affimer allosteric inhibitor fcgr3a]]
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[[Category: Tiede C]]
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[[Category: Immune system]]
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[[Category: Tomlinson DC]]
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[[Category: Waterhouse MP]]

Current revision

Cocrystal structure of Fc gamma receptor IIIa interacting with Affimer G3, a specific binding protein which blocks IgG binding to the receptor.

PDB ID 5mn2

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OCA

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