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5wt5

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==L-homocysteine-bound NifS from Helicobacter pylori==
==L-homocysteine-bound NifS from Helicobacter pylori==
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<StructureSection load='5wt5' size='340' side='right' caption='[[5wt5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5wt5' size='340' side='right'caption='[[5wt5]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5wt5]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WT5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5WT5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5wt5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_26695 Helicobacter pylori 26695]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5WT5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5WT5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HCS:2-AMINO-4-MERCAPTO-BUTYRIC+ACID'>HCS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HCS:2-AMINO-4-MERCAPTO-BUTYRIC+ACID'>HCS</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5wt2|5wt2]], [[5wt4|5wt4]], [[5wt6|5wt6]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5wt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wt5 OCA], [https://pdbe.org/5wt5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5wt5 RCSB], [https://www.ebi.ac.uk/pdbsum/5wt5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5wt5 ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cysteine_desulfurase Cysteine desulfurase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.8.1.7 2.8.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5wt5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5wt5 OCA], [http://pdbe.org/5wt5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5wt5 RCSB], [http://www.ebi.ac.uk/pdbsum/5wt5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5wt5 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ISCS_HELPY ISCS_HELPY]] Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
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[https://www.uniprot.org/uniprot/ISCS_HELPY ISCS_HELPY] Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
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==See Also==
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*[[Cysteine desulfurase 3D structures|Cysteine desulfurase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cysteine desulfurase]]
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[[Category: Helicobacter pylori 26695]]
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[[Category: Fujishiro, T]]
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[[Category: Large Structures]]
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[[Category: Takahashi, Y]]
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[[Category: Fujishiro T]]
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[[Category: Iron-sulfur cluster biogenesis]]
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[[Category: Takahashi Y]]
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[[Category: Transferase]]
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L-homocysteine-bound NifS from Helicobacter pylori

PDB ID 5wt5

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