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6bq1

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==Human PI4KIIIa lipid kinase complex==
==Human PI4KIIIa lipid kinase complex==
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<StructureSection load='6bq1' size='340' side='right' caption='[[6bq1]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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<SX load='6bq1' size='340' side='right' viewer='molstar' caption='[[6bq1]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bq1]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BQ1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E4S:5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E4S:5-{2-amino-1-[4-(morpholin-4-yl)phenyl]-1H-benzimidazol-6-yl}-N-(2-fluorophenyl)-2-methoxypyridine-3-sulfonamide'>E4S</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/1-phosphatidylinositol_4-kinase 1-phosphatidylinositol 4-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.67 2.7.1.67] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [https://pdbe.org/6bq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [https://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bq1 OCA], [http://pdbe.org/6bq1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bq1 RCSB], [http://www.ebi.ac.uk/pdbsum/6bq1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bq1 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/HYCCI_HUMAN HYCCI_HUMAN]] Hypomyelination - congenital cataract. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/PI4KA_HUMAN PI4KA_HUMAN] Bilateral perisylvian polymicrogyria;Autosomal recessive spastic paraplegia type 84;Combined immunodeficiency-enteropathy spectrum. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HYCCI_HUMAN HYCCI_HUMAN]] May have a role in the beta-catenin/Lef signaling pathway. May have a role in the process of myelination of the central and peripheral nervous system.<ref>PMID:16951682</ref>
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[https://www.uniprot.org/uniprot/PI4KA_HUMAN PI4KA_HUMAN] Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate.<ref>PMID:10101268</ref> <ref>PMID:23229899</ref>
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==See Also==
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*[[Phosphatidylinositol 4-kinase|Phosphatidylinositol 4-kinase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: 1-phosphatidylinositol 4-kinase]]
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[[Category: Homo sapiens]]
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[[Category: Baskin, J]]
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[[Category: Large Structures]]
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[[Category: Camilli, P D]]
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[[Category: Baskin J]]
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[[Category: Dobbs, K]]
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[[Category: Camilli PD]]
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[[Category: Lees, J A]]
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[[Category: Dobbs K]]
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[[Category: Notarangelo, L D]]
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[[Category: Lees JA]]
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[[Category: Oh, M]]
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[[Category: Notarangelo LD]]
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[[Category: Reinisch, K M]]
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[[Category: Oh M]]
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[[Category: Schauder, C M]]
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[[Category: Reinisch KM]]
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[[Category: Walz, T]]
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[[Category: Schauder CM]]
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[[Category: Yu, X]]
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[[Category: Walz T]]
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[[Category: Zhang, Y]]
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[[Category: Yu X]]
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[[Category: Kinase]]
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[[Category: Zhang Y]]
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[[Category: Phosphoinositide synthesis]]
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[[Category: Transferase-signaling protein complex]]
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Current revision

Human PI4KIIIa lipid kinase complex

6bq1, resolution 3.60Å

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