1dok

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==MONOCYTE CHEMOATTRACTANT PROTEIN 1, P-FORM==
==MONOCYTE CHEMOATTRACTANT PROTEIN 1, P-FORM==
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<StructureSection load='1dok' size='340' side='right' caption='[[1dok]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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<StructureSection load='1dok' size='340' side='right'caption='[[1dok]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1dok]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DOK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1dok]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DOK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DOK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dok OCA], [http://pdbe.org/1dok PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dok RCSB], [http://www.ebi.ac.uk/pdbsum/1dok PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dok ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dok FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dok OCA], [https://pdbe.org/1dok PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dok RCSB], [https://www.ebi.ac.uk/pdbsum/1dok PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dok ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN]] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
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[https://www.uniprot.org/uniprot/CCL2_HUMAN CCL2_HUMAN] Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/1dok_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/1dok_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
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*[[User:Coline Perrin/CCL2|User:Coline Perrin/CCL2]]
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*[[Monocyte chemoattractant protein|Monocyte chemoattractant protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Boque, L]]
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[[Category: Large Structures]]
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[[Category: Bujacz, G]]
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[[Category: Boque L]]
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[[Category: Domaille, P J]]
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[[Category: Bujacz G]]
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[[Category: Handel, T M]]
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[[Category: Domaille PJ]]
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[[Category: Lubkowski, J]]
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[[Category: Handel TM]]
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[[Category: Wlodawer, A]]
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[[Category: Lubkowski J]]
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[[Category: Chemoattractant]]
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[[Category: Wlodawer A]]
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[[Category: Cytokine]]
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Current revision

MONOCYTE CHEMOATTRACTANT PROTEIN 1, P-FORM

PDB ID 1dok

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