This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1e2i

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:10, 6 December 2023) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
==The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography==
==The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography==
-
<StructureSection load='1e2i' size='340' side='right' caption='[[1e2i]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+
<StructureSection load='1e2i' size='340' side='right'caption='[[1e2i]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[1e2i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hhv-1 Hhv-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E2I FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[1e2i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E2I FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=APS:9-HYDROXYPROPYLADENINE,+S-ISOMER'>APS</scene>, <scene name='pdbligand=ARP:9-HYDROXYPROPYLADENINE,+R-ISOMER'>ARP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kim|1kim]], [[1vtk|1vtk]], [[2vtk|2vtk]], [[3vtk|3vtk]], [[1ki2|1ki2]], [[1ki4|1ki4]], [[1ki5|1ki5]], [[1ki6|1ki6]], [[1ki7|1ki7]], [[1ki8|1ki8]], [[1e2j|1e2j]], [[1e2h|1e2h]], [[1e2k|1e2k]], [[1e2l|1e2l]], [[1e2m|1e2m]], [[1e2n|1e2n]], [[1e2p|1e2p]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=APS:9-HYDROXYPROPYLADENINE,+S-ISOMER'>APS</scene>, <scene name='pdbligand=ARP:9-HYDROXYPROPYLADENINE,+R-ISOMER'>ARP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2i OCA], [https://pdbe.org/1e2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e2i RCSB], [https://www.ebi.ac.uk/pdbsum/1e2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2i ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e2i OCA], [http://pdbe.org/1e2i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e2i RCSB], [http://www.ebi.ac.uk/pdbsum/1e2i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e2i ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11]] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
+
[https://www.uniprot.org/uniprot/KITH_HHV11 KITH_HHV11] In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 30: Line 29:
</div>
</div>
<div class="pdbe-citations 1e2i" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1e2i" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Thymidine kinase 3D structures|Thymidine kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Hhv-1]]
+
[[Category: Human alphaherpesvirus 1 strain 17]]
-
[[Category: Thymidine kinase]]
+
[[Category: Large Structures]]
-
[[Category: Scapozza, L]]
+
[[Category: Scapozza L]]
-
[[Category: Schulz, G E]]
+
[[Category: Schulz GE]]
-
[[Category: Vogt, J]]
+
[[Category: Vogt J]]
-
[[Category: Adenine analog]]
+
-
[[Category: Enzyme-prodrug gene therapy]]
+
-
[[Category: Nucleoside- binding]]
+
-
[[Category: Transferase]]
+

Current revision

The nucleoside binding site of Herpes simplex type 1 thymidine kinase analyzed by X-ray crystallography

PDB ID 1e2i

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1e2i"
Personal tools