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| | ==Solution Structure of the Major Cherry Allergen Pru av 1== | | ==Solution Structure of the Major Cherry Allergen Pru av 1== |
| - | <StructureSection load='1e09' size='340' side='right' caption='[[1e09]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''> | + | <StructureSection load='1e09' size='340' side='right'caption='[[1e09]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[1e09]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cerasus_avium Cerasus avium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E09 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1E09 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1e09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Prunus_avium Prunus avium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E09 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1btv|1btv]], [[1b6f|1b6f]], [[1bv1|1bv1]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1e09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e09 OCA], [http://pdbe.org/1e09 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1e09 RCSB], [http://www.ebi.ac.uk/pdbsum/1e09 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1e09 ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e09 OCA], [https://pdbe.org/1e09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e09 RCSB], [https://www.ebi.ac.uk/pdbsum/1e09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e09 ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/PRU1_PRUAV PRU1_PRUAV] |
| | == Evolutionary Conservation == | | == Evolutionary Conservation == |
| | [[Image:Consurf_key_small.gif|200px|right]] | | [[Image:Consurf_key_small.gif|200px|right]] |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Cerasus avium]] | + | [[Category: Large Structures]] |
| - | [[Category: Boehm, M]] | + | [[Category: Prunus avium]] |
| - | [[Category: Nerkamp, J]] | + | [[Category: Boehm M]] |
| - | [[Category: Neudecker, P]] | + | [[Category: Nerkamp J]] |
| - | [[Category: Roesch, P]] | + | [[Category: Neudecker P]] |
| - | [[Category: Scheurer, S]] | + | [[Category: Roesch P]] |
| - | [[Category: Schweimer, K]] | + | [[Category: Scheurer S]] |
| - | [[Category: Sticht, H]] | + | [[Category: Schweimer K]] |
| - | [[Category: Vieths, S]] | + | [[Category: Sticht H]] |
| - | [[Category: Allergen]]
| + | [[Category: Vieths S]] |
| - | [[Category: Heteronuclear nmr]]
| + | |
| - | [[Category: Major cherry allergen]]
| + | |
| - | [[Category: Pathogenesis-related protein]]
| + | |
| Structural highlights
Function
PRU1_PRUAV
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Birch pollinosis is often accompanied by hypersensitivity to fruit as a consequence of the cross-reaction of pollen allergen-specific IgE antibodies with homologous food proteins. To provide a basis for examining the cross-reactivity on a structural level, we used heteronuclear multidimensional NMR spectroscopy to determine the high-resolution three-dimensional structure of the major cherry allergen, Pru av 1, in solution. Based on a detailed comparison of the virtually identical structures of Pru av 1 and Bet v 1, the major birch pollen allergen, we propose an explanation for a significant aspect of the observed cross-reactivity pattern among the family of allergens under consideration. The large hydrophobic cavity expected to be important for the still unknown physiological function of Bet v 1 is conserved in Pru av 1. Structural homology to a domain of human MLN64 associated with cholesterol transport suggests phytosteroids as putative ligands for Pru av 1. NMR spectroscopy provides experimental evidence that Pru av 1 interacts with phytosteroids, and molecular modeling shows that the hydrophobic cavity is large enough to accommodate two such molecules.
Allergic cross-reactivity made visible: solution structure of the major cherry allergen Pru av 1.,Neudecker P, Schweimer K, Nerkamp J, Scheurer S, Vieths S, Sticht H, Rosch P J Biol Chem. 2001 Jun 22;276(25):22756-63. Epub 2001 Apr 3. PMID:11287426[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Neudecker P, Schweimer K, Nerkamp J, Scheurer S, Vieths S, Sticht H, Rosch P. Allergic cross-reactivity made visible: solution structure of the major cherry allergen Pru av 1. J Biol Chem. 2001 Jun 22;276(25):22756-63. Epub 2001 Apr 3. PMID:11287426 doi:10.1074/jbc.M101657200
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