2chy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:18, 14 February 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2chy.jpg|left|200px]]
 
-
{{Structure
+
==THREE-DIMENSIONAL STRUCTURE OF CHEY, THE RESPONSE REGULATOR OF BACTERIAL CHEMOTAXIS==
-
|PDB= 2chy |SIZE=350|CAPTION= <scene name='initialview01'>2chy</scene>, resolution 2.7&Aring;
+
<StructureSection load='2chy' size='340' side='right'caption='[[2chy]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND=
+
<table><tr><td colspan='2'>[[2chy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CHY FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
-
|GENE=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2chy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chy OCA], [https://pdbe.org/2chy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2chy RCSB], [https://www.ebi.ac.uk/pdbsum/2chy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2chy ProSAT]</span></td></tr>
-
|DOMAIN=
+
</table>
-
|RELATEDENTRY=
+
== Function ==
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2chy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2chy OCA], [http://www.ebi.ac.uk/pdbsum/2chy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2chy RCSB]</span>
+
[https://www.uniprot.org/uniprot/CHEY_SALTY CHEY_SALTY] Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. In its active (phosphorylated or acetylated) form, CheY exhibits enhanced binding to a switch component, FliM, at the flagellar motor which induces a change from counterclockwise to clockwise flagellar rotation. Shows autophosphatase activity which is enhanced by CheZ.
-
}}
+
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ch/2chy_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2chy ConSurf].
 +
<div style="clear:both"></div>
-
'''THREE-DIMENSIONAL STRUCTURE OF CHEY, THE RESPONSE REGULATOR OF BACTERIAL CHEMOTAXIS'''
+
==See Also==
-
 
+
*[[Chemotaxis protein 3D structures|Chemotaxis protein 3D structures]]
-
 
+
*[[Receiver domain of sensor histidine kinase CKI1|Receiver domain of sensor histidine kinase CKI1]]
-
==Overview==
+
__TOC__
-
Homologies among bacterial signal transduction proteins suggest that a common mechanism mediates processes such as chemotaxis, osmoregulation, sporulation, virulence, and responses to nitrogen, phosphorous and oxygen deprivation. A common kinase-mediated phosphotransfer reaction has recently been identified in chemotaxis, nitrogen regulation, and osmoregulation. In chemotaxis, the CheA kinase passes a phosphoryl group to the cytoplasmic protein CheY, which functions as a phosphorylation-activated switch that interacts with flagellar components to regulate motility. We report here the X-ray crystal structure of the Salmonella typhimurium CheY protein. The determination of the structure was facilitated by the use of site-specific mutagenesis to engineer heavy-atom binding sites. CheY is a single-domain protein composed of a doubly wound five-stranded parallel beta-sheet. The phosphoacceptor site in CheY is probably a cluster of aspartic-acid side chains near the C-terminal edge of the beta-sheet. The pattern of sequence similarity of CheY with components of other regulatory systems can be interpreted in the light of the CheY structure and supports the view that this family of proteins have a common structural motif and active site.
+
</StructureSection>
-
 
+
[[Category: Large Structures]]
-
==About this Structure==
+
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
-
2CHY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CHY OCA].
+
[[Category: Mottonen JM]]
-
 
+
[[Category: Schutt CE]]
-
==Reference==
+
[[Category: Stock AM]]
-
Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis., Stock AM, Mottonen JM, Stock JB, Schutt CE, Nature. 1989 Feb 23;337(6209):745-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2645526 2645526]
+
[[Category: Stock JB]]
-
[[Category: Salmonella typhimurium]]
+
-
[[Category: Single protein]]
+
-
[[Category: Mottonen, J M.]]
+
-
[[Category: Schutt, C E.]]
+
-
[[Category: Stock, A M.]]
+
-
[[Category: Stock, J B.]]
+
-
[[Category: signal transduction protein]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:21:47 2008''
+

Current revision

THREE-DIMENSIONAL STRUCTURE OF CHEY, THE RESPONSE REGULATOR OF BACTERIAL CHEMOTAXIS

PDB ID 2chy

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2chy"
Personal tools