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5nqa

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==Crystal structure of GalNAc-T4 in complex with the monoglycopeptide 3==
==Crystal structure of GalNAc-T4 in complex with the monoglycopeptide 3==
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<StructureSection load='5nqa' size='340' side='right' caption='[[5nqa]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5nqa' size='340' side='right'caption='[[5nqa]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nqa]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NQA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5NQA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nqa]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NQA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NQA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polypeptide_N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.41 2.4.1.41] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NGA:N-ACETYL-D-GALACTOSAMINE'>NGA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5nqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nqa OCA], [http://pdbe.org/5nqa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nqa RCSB], [http://www.ebi.ac.uk/pdbsum/5nqa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nqa ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nqa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nqa OCA], [https://pdbe.org/5nqa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nqa RCSB], [https://www.ebi.ac.uk/pdbsum/5nqa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nqa ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GALT4_HUMAN GALT4_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.
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[https://www.uniprot.org/uniprot/GALT4_HUMAN GALT4_HUMAN] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward Muc7, EA2 and Muc2, with a lowest activity than GALNT2. Glycosylates 'Thr-57' of SELPLG.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Polypeptide N-acetylgalactosaminyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Clausen, H]]
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[[Category: Large Structures]]
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[[Category: Coelho, H]]
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[[Category: Clausen H]]
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[[Category: Companon, I]]
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[[Category: Coelho H]]
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[[Category: Corzana, F]]
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[[Category: Companon I]]
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[[Category: Daniel, E J.P]]
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[[Category: Corzana F]]
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[[Category: Diniz, A]]
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[[Category: Daniel EJP]]
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[[Category: Gerken, T A]]
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[[Category: Diniz A]]
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[[Category: Hurtado-Guerrero, R]]
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[[Category: Gerken TA]]
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[[Category: Jimenez-Barbero, J]]
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[[Category: Hurtado-Guerrero R]]
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[[Category: Jimenez-Oses, G]]
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[[Category: Jimenez-Barbero J]]
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[[Category: Lira-Navarrete, E]]
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[[Category: Jimenez-Oses G]]
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[[Category: Marcelo, F]]
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[[Category: Lira-Navarrete E]]
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[[Category: Peregrina, J M]]
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[[Category: Marcelo F]]
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[[Category: Rivas, M de las]]
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[[Category: Peregrina JM]]
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[[Category: Chimera]]
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[[Category: De las Rivas M]]
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[[Category: Flexible linker]]
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[[Category: Galnac-t2]]
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[[Category: Galnac-t4]]
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[[Category: Glycosylation preference]]
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[[Category: Std-nmr]]
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[[Category: Transferase]]
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Current revision

Crystal structure of GalNAc-T4 in complex with the monoglycopeptide 3

PDB ID 5nqa

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