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5n88

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==Crystal structure of antibody bound to viral protein==
==Crystal structure of antibody bound to viral protein==
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<StructureSection load='5n88' size='340' side='right' caption='[[5n88]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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<StructureSection load='5n88' size='340' side='right'caption='[[5n88]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5n88]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N88 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5N88 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5n88]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5N88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5N88 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n88 OCA], [http://pdbe.org/5n88 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5n88 RCSB], [http://www.ebi.ac.uk/pdbsum/5n88 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5n88 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5n88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5n88 OCA], [https://pdbe.org/5n88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5n88 RCSB], [https://www.ebi.ac.uk/pdbsum/5n88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5n88 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
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[https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Note=A chromosomal aberration involving PSIP1 is associated with pediatric acute myeloid leukemia (AML) with intermediate characteristics between M2-M3 French-American-British (FAB) subtypes. Translocation t(9;11)(p22;p15) with NUP98. The chimeric transcript is an in-frame fusion of NUP98 exon 8 to PSIP1/LEDGF exon 4.
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN]] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref>
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[https://www.uniprot.org/uniprot/PSIP1_HUMAN PSIP1_HUMAN] Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis. Isoform 2 is a more general and stronger transcriptional coactivator. Isoform 2 may also act as an adapter to coordinate pre-mRNA splicing. Cellular cofactor for lentiviral integration.<ref>PMID:15642333</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5n88" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5n88" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bao, L]]
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[[Category: Homo sapiens]]
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[[Category: Bunjobpol, W]]
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[[Category: Large Structures]]
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[[Category: Chambers, J S]]
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[[Category: Bao L]]
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[[Category: Cruz-Migoni, A]]
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[[Category: Bunjobpol W]]
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[[Category: Derveni, M]]
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[[Category: Chambers JS]]
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[[Category: Hannon, C]]
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[[Category: Cruz-Migoni A]]
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[[Category: Phillips, S E.V]]
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[[Category: Derveni M]]
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[[Category: Ptchelkine, D]]
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[[Category: Hannon C]]
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[[Category: Rabbitts, T H]]
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[[Category: Phillips SEV]]
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[[Category: Simmons, A]]
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[[Category: Ptchelkine D]]
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[[Category: Sun, M y]]
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[[Category: Rabbitts TH]]
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[[Category: Aid]]
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[[Category: Simmons A]]
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[[Category: Immune system]]
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[[Category: Sun M-y]]
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[[Category: Mll: hiv: intracellular antibody: integrase: ledgf]]
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Current revision

Crystal structure of antibody bound to viral protein

PDB ID 5n88

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OCA

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