5qca

<StructureSection load='5qca' size='340' side='right' caption='[[5qca]], [[Resolution|resolution]] 2.29&Aring;' scene=''>

<table><tr><td colspan='2'>[[5qca]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QCA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QCA FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BGJ:1-{4-[(2-chloro-5-{1-[3-(4-cyclopropylpiperazin-1-yl)propyl]-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]phenyl}-N-[(4-chlorophenyl)methyl]methanamine'>BGJ</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qca FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qca OCA], [http://pdbe.org/5qca PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qca RCSB], [http://www.ebi.ac.uk/pdbsum/5qca PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qca ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

[[Category: Cathepsin S]]

[[Category: Ameriks, M K]]

[[Category: Bembenek, S D]]

[[Category: Burley, S K]]

[[Category: Mirzadegan, T]]

[[Category: Shao, C]]

[[Category: Yang, H]]

[[Category: Ligand docking]]