6bn6

<StructureSection load='6bn6' size='340' side='right' caption='[[6bn6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[6bn6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BN6 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=XGH:2-[(2S)-4-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-3,4-dihydro-2H-1,4-benzothiazin-2-yl]-N-(2-hydroxy-2-methylpropyl)acetamide'>XGH</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bn6 OCA], [http://pdbe.org/6bn6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bn6 RCSB], [http://www.ebi.ac.uk/pdbsum/6bn6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bn6 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.

[[Category: Sack, J]]

[[Category: Inverse agonist]]

[[Category: Ligand-binding domain]]

[[Category: Transcription-transcription inhibitor complex]]