6bo8

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==Cryo-EM structure of human TRPV6 in nanodiscs==
==Cryo-EM structure of human TRPV6 in nanodiscs==
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<StructureSection load='6bo8' size='340' side='right' caption='[[6bo8]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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<SX load='6bo8' size='340' side='right' viewer='molstar' caption='[[6bo8]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6bo8]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BO8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6BO8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6bo8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BO8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BO8 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6bo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bo8 OCA], [http://pdbe.org/6bo8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6bo8 RCSB], [http://www.ebi.ac.uk/pdbsum/6bo8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6bo8 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bo8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bo8 OCA], [https://pdbe.org/6bo8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bo8 RCSB], [https://www.ebi.ac.uk/pdbsum/6bo8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bo8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TRPV6_HUMAN TRPV6_HUMAN]] Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.[UniProtKB:Q91WD2]<ref>PMID:11097838</ref> <ref>PMID:11248124</ref> <ref>PMID:11278579</ref> <ref>PMID:15184369</ref> <ref>PMID:23612980</ref>
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[https://www.uniprot.org/uniprot/TRPV6_HUMAN TRPV6_HUMAN] Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine (PubMed:11097838, PubMed:11278579, PubMed:11248124 PubMed:15184369, PubMed:23612980). Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification (PubMed:15184369). Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.[UniProtKB:Q91WD2]<ref>PMID:11097838</ref> <ref>PMID:11248124</ref> <ref>PMID:11278579</ref> <ref>PMID:15184369</ref> <ref>PMID:23612980</ref>
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==See Also==
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Grassucci, R A]]
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[[Category: Homo sapiens]]
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[[Category: McGoldrick, L L]]
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[[Category: Large Structures]]
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[[Category: Saotome, K]]
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[[Category: Grassucci RA]]
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[[Category: Singh, A K]]
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[[Category: McGoldrick LL]]
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[[Category: Sobolevsky, A I]]
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[[Category: Saotome K]]
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[[Category: Twomey, E C]]
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[[Category: Singh AK]]
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[[Category: Yelshanskaya, M V]]
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[[Category: Sobolevsky AI]]
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[[Category: Ion channel]]
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[[Category: Twomey EC]]
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[[Category: Membrane protein]]
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[[Category: Yelshanskaya MV]]
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[[Category: Transport protein]]
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Current revision

Cryo-EM structure of human TRPV6 in nanodiscs

6bo8, resolution 3.60Å

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