5q0r
From Proteopedia
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==Ligand binding to FARNESOID-X-RECEPTOR== | ==Ligand binding to FARNESOID-X-RECEPTOR== | ||
- | <StructureSection load='5q0r' size='340' side='right' caption='[[5q0r]], [[Resolution|resolution]] 1.91Å' scene=''> | + | <StructureSection load='5q0r' size='340' side='right'caption='[[5q0r]], [[Resolution|resolution]] 1.91Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[5q0r]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5q0r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q0R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Q0R FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9LG:N,1-dibenzyl-6-[(2-fluorophenyl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide'>9LG</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9LG:N,1-dibenzyl-6-[(2-fluorophenyl)sulfonyl]-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-2-carboxamide'>9LG</scene></td></tr> | |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5q0r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q0r OCA], [https://pdbe.org/5q0r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5q0r RCSB], [https://www.ebi.ac.uk/pdbsum/5q0r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5q0r ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5q0r" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5q0r" style="background-color:#fffaf0;"></div> | ||
+ | |||
+ | ==See Also== | ||
+ | *[[Bile acid receptor 3D structures|Bile acid receptor 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
- | [[Category: Benz | + | [[Category: Large Structures]] |
- | [[Category: Burger | + | [[Category: Benz J]] |
- | [[Category: Burley | + | [[Category: Burger D]] |
- | [[Category: Joseph | + | [[Category: Burley SK]] |
- | [[Category: Kuhn | + | [[Category: Joseph C]] |
- | [[Category: Rudolph | + | [[Category: Kuhn B]] |
- | [[Category: Ruf | + | [[Category: Rudolph MG]] |
- | [[Category: Shao | + | [[Category: Ruf A]] |
- | [[Category: Thoma | + | [[Category: Shao C]] |
- | [[Category: Yang | + | [[Category: Thoma R]] |
- | + | [[Category: Yang H]] | |
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Current revision
Ligand binding to FARNESOID-X-RECEPTOR
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Categories: Homo sapiens | Large Structures | Benz J | Burger D | Burley SK | Joseph C | Kuhn B | Rudolph MG | Ruf A | Shao C | Thoma R | Yang H