Microtubule-associated serine/threonine kinase

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'''Microtubule_associated serine/threonine kinase''' (MAST) belongs to a family of proteins which contain a serine/threonine kinase domain and a PDZ domain.
'''Microtubule_associated serine/threonine kinase''' (MAST) belongs to a family of proteins which contain a serine/threonine kinase domain and a PDZ domain.
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'''MAST1''' associates with the cytoskeleton and can bind through its PDZ domain both β-2-synthrophin and neuronal nitric oxide synthase. '''MAST2''' regulates
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lipopolysaccharide-induced IL-12 synthesis.
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*'''MAST1''' associates with the cytoskeleton and can bind through its PDZ domain both β-2-synthrophin and neuronal nitric oxide synthase.
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*'''MAST2''' regulates lipopolysaccharide-induced IL-12 synthesis.
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*'''MAST L''' supports mitosis by phosphorylating PP2A/B55<ref>PMID:36354735</ref>
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Microtubule_associated serine/threonine kinase 1
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*Microtubule-associated serine/threonine kinase 1
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**[[3ps4]] – MAST1 PDZ domain 965-1057 – human <br />
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**[[3ps4]] – hMAST1 PDZ domain 965-1057 – human <br />
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**[[2m9x]] – MAST1 residues 187-287 – NMR <br />
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**[[2m9x]] – hMAST1 residues 187-287 – NMR <br />
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*Microtubule_associated serine/threonine kinase 2
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*Microtubule-associated serine/threonine kinase 2
**[[2kqf]], [[2kyl]] – hMAST2 PDZ domain + glycoprotein C-terminal - NMR<br />
**[[2kqf]], [[2kyl]] – hMAST2 PDZ domain + glycoprotein C-terminal - NMR<br />
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*Microtubule_associated serine/threonine kinase 3
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*Microtubule-associated serine/threonine kinase 3
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**[[2w7r]] – hMAST3 PDZ domain <br />
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*Microtubule_associated serine/threonine kinase 4
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**[[3khf]] – hMAST3 PDZ domain <br />
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**[[3khf]] – hMAST4 PDZ domain <br />
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*Microtubule-associated serine/threonine kinase 4
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**[[2w7r]] – hMAST4 PDZ domain <br />
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*Microtubule_associated serine/threonine kinase-like or Greatwall
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*Microtubule-associated serine/threonine kinase-like or Greatwall
**[[5loh]] – hMAST-L kinase domain <br />
**[[5loh]] – hMAST-L kinase domain <br />

Current revision

Human Microtubule_associated serine/threonine kinase 1 PDZ domain complex with imidazole and ethylene glycol (PDB code 3ps4)

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3D Structures of microtubule-associated serine/threonine kinase

Updated on 11-July-2024

References

  1. ↑ Sanz-Castillo B, Hurtado B, Vara-Ciruelos D, El Bakkali A, Hermida D, Salvador-Barbero B, Martínez-Alonso D, González-Martínez J, Santiveri C, Campos-Olivas R, Ximénez-Embún P, Muñoz J, Álvarez-Fernández M, Malumbres M. The MASTL/PP2A cell cycle kinase-phosphatase module restrains PI3K-Akt activity in an mTORC1-dependent manner. EMBO J. 2023 Jan 16;42(2):e110833. PMID:36354735 doi:10.15252/embj.2022110833

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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