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2cmw

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[[Image:2cmw.gif|left|200px]]
 
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{{Structure
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==Structure of Human Casein kinase 1 gamma-1 in complex with 2-(2- Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine==
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|PDB= 2cmw |SIZE=350|CAPTION= <scene name='initialview01'>2cmw</scene>, resolution 1.75&Aring;
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<StructureSection load='2cmw' size='340' side='right'caption='[[2cmw]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Act+Binding+Site+For+Chain+A'>AC1</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=OLP:2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE'>OLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SCS:S,S-ETHYLTHIOCYSTEINE'>SCS</scene>
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<table><tr><td colspan='2'>[[2cmw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMW FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=OLP:2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE'>OLP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SCS:3-(ETHYLDISULFANYL)-L-ALANINE'>SCS</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmw OCA], [https://pdbe.org/2cmw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmw RCSB], [https://www.ebi.ac.uk/pdbsum/2cmw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmw ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cmw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmw OCA], [http://www.ebi.ac.uk/pdbsum/2cmw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cmw RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/KC1G1_HUMAN KC1G1_HUMAN] Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). Phosphorylates CLSPN.<ref>PMID:21680713</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cm/2cmw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cmw ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF HUMAN CASEIN KINASE 1 GAMMA-1 IN COMPLEX WITH 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE (CASP TARGET)'''
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==See Also==
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*[[Casein kinase 3D structures|Casein kinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2CMW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMW OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Arrowsmith C]]
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[[Category: Arrowsmith, C.]]
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[[Category: Bunkoczi G]]
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[[Category: Bunkoczi, G.]]
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[[Category: Das S]]
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[[Category: Das, S.]]
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[[Category: Edwards A]]
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[[Category: Delft, F Von.]]
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[[Category: Fedorov O]]
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[[Category: Edwards, A.]]
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[[Category: Knapp S]]
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[[Category: Fedorov, O.]]
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[[Category: Niesen F]]
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[[Category: Knapp, S.]]
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[[Category: Pike ACW]]
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[[Category: Niesen, F.]]
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[[Category: Rellos P]]
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[[Category: Pike, A C.W.]]
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[[Category: Savitsky P]]
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[[Category: Rellos, P.]]
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[[Category: Sobott F]]
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[[Category: Savitsky, P.]]
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[[Category: Sundstrom M]]
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[[Category: Sobott, F.]]
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[[Category: Weigelt J]]
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[[Category: Sundstrom, M.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: alternative splicing]]
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[[Category: atp-binding]]
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[[Category: kinase]]
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[[Category: nucleotide-binding]]
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[[Category: phosphorylation]]
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[[Category: serine/threonine protein kinase]]
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[[Category: serine/threonine-protein kinase]]
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[[Category: transferase]]
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[[Category: wnt signaling pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:23:43 2008''
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Current revision

Structure of Human Casein kinase 1 gamma-1 in complex with 2-(2- Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine

PDB ID 2cmw

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