6bnm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the P-Rex2 PH domain== | |
| - | + | <StructureSection load='6bnm' size='340' side='right'caption='[[6bnm]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6bnm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BNM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bnm OCA], [https://pdbe.org/6bnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bnm RCSB], [https://www.ebi.ac.uk/pdbsum/6bnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bnm ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PREX2_HUMAN PREX2_HUMAN] Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.<ref>PMID:15304342</ref> <ref>PMID:15304343</ref> <ref>PMID:15897194</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cash JN]] | ||
| + | [[Category: Sharma PV]] | ||
| + | [[Category: Tesmer JJG]] | ||
Current revision
Crystal Structure of the P-Rex2 PH domain
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