6bx9
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of conotoxin reg3b== | |
| + | <StructureSection load='6bx9' size='340' side='right'caption='[[6bx9]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6bx9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_regius Conus regius]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BX9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BX9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bx9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bx9 OCA], [https://pdbe.org/6bx9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bx9 RCSB], [https://www.ebi.ac.uk/pdbsum/6bx9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bx9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CM3B_CONRE CM3B_CONRE] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The mini-M conotoxins are peptidic scaffolds found in the venom of cones snails. These scaffolds are tightly folded structures held together by three disulfide bonds with a CC-C-C-CC arrangement (conotoxin framework III) and belong to the M Superfamily of conotoxins. Here, we describe mini-M conotoxins from the venom of Conus regius, a Western Atlantic worm-hunting cone snail species using transcriptomic and peptidomic analyses. These C. regius conotoxins belong to three different subtypes: M1, M2, and M3. The subtypes show little sequence homology, and their loop sizes (intercysteine amino acid chains) vary significantly. The mini-Ms isolated from dissected venom contains preferentially hydroxylated proline residues, thus augmenting the structural reach of this conotoxin class. Using 2D-NMR methods, we have determined the 3D structure of reg3b, an M2 subtype conotoxin, which shows a constrained multi-turn scaffold. The structural diversity found within mini-M conotoxin scaffolds of C. regius is indicative of structural hypervariability of the conotoxin M superfamily that is not seen in other superfamilies. These stable minimalistic scaffolds may be investigated for the development of engineered peptides for therapeutic applications. DATABASES: Sequences are available in GenBank under accession numbers MF588935-MF588952. Structural data are available in the RCSB protein database under the accession code 6BX9. | ||
| - | + | Structural plasticity of mini-M conotoxins - expression of all mini-M subtypes by Conus regius.,Franco A, Dovell S, Moller C, Grandal M, Clark E, Mari F FEBS J. 2017 Dec 28. doi: 10.1111/febs.14372. PMID:29283511<ref>PMID:29283511</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6bx9" style="background-color:#fffaf0;"></div> |
| - | [[Category: Dovell | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Conus regius]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Dovell S]] | ||
| + | [[Category: Mari F]] | ||
Current revision
Solution structure of conotoxin reg3b
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