6fae

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "6fae" [edit=sysop:move=sysop])
Current revision (12:26, 9 May 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6fae is ON HOLD until Paper Publication
+
==The Sec7 domain of IQSEC2 (Brag1) in complex with the small GTPase Arf1==
 +
<StructureSection load='6fae' size='340' side='right'caption='[[6fae]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6fae]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FAE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FAE FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fae FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fae OCA], [https://pdbe.org/6fae PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fae RCSB], [https://www.ebi.ac.uk/pdbsum/6fae PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fae ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ARF1_HUMAN ARF1_HUMAN] GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking among different compartments. Modulates vesicle budding and uncoating within the Golgi complex. Deactivation induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, suggesting a crucial role in protein trafficking. In its GTP-bound form, its triggers the association with coat proteins with the Golgi membrane. The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The Ras superfamily of small GTPases are guanine nucleotide dependent switches essential for numerous cellular processes. Mutations or dysregulation of these proteins are associated with many diseases, but unsuccessful attempts to target the small GTPases directly have resulted in them being classed as 'undruggable'. The GTP dependent signaling of these proteins is controlled by their regulators; guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs), and in the Rho and Rab subfamilies, guanine nucleotide dissociation inhibitors (GDIs). This review covers the recent small molecule and biologics strategies to target the small GTPases through their regulators. It seeks to critically re-evaluate recent chemical biology practice, such as the presence of PAINs motifs and the cell-based readout using compounds that are weakly potent or of unknown specificity. It highlights the vast scope of potential approaches for targeting the small GTPases in the future through their regulatory proteins.
-
Authors: Gray, J., Krojer, T., Fairhead, M., Bountra, C., Arrowsmith, C.H., Edwards, A., Brennan, P., von Delft, F.
+
Targeting the Small GTPase Superfamily through their Regulatory Proteins.,Gray JL, von Delft F, Brennan P Angew Chem Int Ed Engl. 2019 Mar 14. doi: 10.1002/anie.201900585. PMID:30869179<ref>PMID:30869179</ref>
-
Description: The Sec7 domain of IQSEC2 (Brag1) in complex with the small GTPase Arf1
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Arrowsmith, C.H]]
+
<div class="pdbe-citations 6fae" style="background-color:#fffaf0;"></div>
-
[[Category: Gray, J]]
+
== References ==
-
[[Category: Fairhead, M]]
+
<references/>
-
[[Category: Von Delft, F]]
+
__TOC__
-
[[Category: Edwards, A]]
+
</StructureSection>
-
[[Category: Krojer, T]]
+
[[Category: Homo sapiens]]
-
[[Category: Brennan, P]]
+
[[Category: Large Structures]]
-
[[Category: Bountra, C]]
+
[[Category: Arrowsmith CH]]
 +
[[Category: Bountra C]]
 +
[[Category: Brennan P]]
 +
[[Category: Edwards A]]
 +
[[Category: Fairhead M]]
 +
[[Category: Gray J]]
 +
[[Category: Krojer T]]
 +
[[Category: Von Delft F]]

Current revision

The Sec7 domain of IQSEC2 (Brag1) in complex with the small GTPase Arf1

PDB ID 6fae

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6fae"
Personal tools