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3zrb
From Proteopedia
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==Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators== | ==Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators== | ||
| - | <StructureSection load='3zrb' size='340' side='right' caption='[[3zrb]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='3zrb' size='340' side='right'caption='[[3zrb]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3zrb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZRB FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=OR8:2-CHLORO-N-[[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]METHYL]-1,4-DIMETHYL-1H-PYRAZOLE-4-SULFONAMIDE'>OR8</scene>, <scene name='pdbligand=ORC:(R)-N-[1-[4-(3,5-DIMETHYLISOXAZOL-4-YL)PHENYL]ETHYL]-3,5-DIMETHYLISOXAZOLE-4-SULFONAMIDE'>ORC</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zrb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zrb OCA], [https://pdbe.org/3zrb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zrb RCSB], [https://www.ebi.ac.uk/pdbsum/3zrb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zrb ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PRGR_HUMAN PRGR_HUMAN] The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> Isoform A is inactive in stimulating c-Src/MAPK signaling on hormone stimulation.<ref>PMID:15572662</ref> <ref>PMID:15798179</ref> <ref>PMID:17020914</ref> <ref>PMID:17347654</ref> <ref>PMID:17717077</ref> <ref>PMID:17173941</ref> <ref>PMID:18202149</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 3zrb" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 3zrb" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Progesterone receptor|Progesterone receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Azevedo R]] |
| - | [[Category: | + | [[Category: Brown AR]] |
| - | [[Category: | + | [[Category: Dechering K]] |
| - | [[Category: | + | [[Category: Hamilton NM]] |
| - | [[Category: Lusher | + | [[Category: Lusher SJ]] |
| - | [[Category: Mcguire | + | [[Category: Mcguire R]] |
| - | [[Category: Nimz | + | [[Category: Nimz O]] |
| - | [[Category: Oubrie | + | [[Category: Oubrie A]] |
| - | [[Category: Raaijmakers | + | [[Category: Raaijmakers HCA]] |
| - | + | [[Category: Vu-Pham D]] | |
| - | [[Category: Vu-Pham | + | [[Category: Wai Lam T]] |
| - | [[Category: | + | [[Category: De Vlieg J]] |
| - | [[Category: | + | |
| - | + | ||
Current revision
Structural basis for agonism and antagonism for a set of chemically related progesterone receptor modulators
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Categories: Homo sapiens | Large Structures | Azevedo R | Brown AR | Dechering K | Hamilton NM | Lusher SJ | Mcguire R | Nimz O | Oubrie A | Raaijmakers HCA | Vu-Pham D | Wai Lam T | De Vlieg J
