2cs7

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[[Image:2cs7.gif|left|200px]]
 
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{{Structure
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==1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold==
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|PDB= 2cs7 |SIZE=350|CAPTION= <scene name='initialview01'>2cs7</scene>, resolution 1.20&Aring;
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<StructureSection load='2cs7' size='340' side='right'caption='[[2cs7]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2cs7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CS7 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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|GENE= PhtA (18-220) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cs7 OCA], [https://pdbe.org/2cs7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cs7 RCSB], [https://www.ebi.ac.uk/pdbsum/2cs7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cs7 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2cs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cs7 OCA], [http://www.ebi.ac.uk/pdbsum/2cs7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2cs7 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/A0A0H2UQ89_STRPN A0A0H2UQ89_STRPN]
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== Evolutionary Conservation ==
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'''1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cs/2cs7_consurf.spt"</scriptWhenChecked>
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The recently described pneumococcal histidine triad protein family has been shown to be highly conserved within the pneumococcus. As part of our structural genomics effort on proteins from Streptococcus pneumoniae, we have expressed, crystallised and solved the structure of PhtA-166-220 at 1.2 Angstroms using remote SAD with zinc. The structure of PhtA-166-220 shows no similarity to any protein structure. The overall fold contains 3beta-strands and a single short alpha-helix. The structure appears to contain a novel zinc binding motif. The remaining 4 histidine triad repeats from PhtA have been modelled based on the crystal structure of the PhtA histidine triad repeat 2. From this modelling work, we speculate that only three of the five histidine triad repeats contain the residues in the correct geometry to allow the binding of a zinc ion.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2CS7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CS7 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cs7 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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1.2 Angstroms crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold., Riboldi-Tunnicliffe A, Isaacs NW, Mitchell TJ, FEBS Lett. 2005 Oct 10;579(24):5353-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16194532 16194532]
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</StructureSection>
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[[Category: Single protein]]
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[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: Isaacs, N W.]]
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[[Category: Isaacs NW]]
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[[Category: Mitchell, T J.]]
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[[Category: Mitchell TJ]]
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[[Category: Riboldi-Tunnicliffe, A.]]
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[[Category: Riboldi-Tunnicliffe A]]
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[[Category: phta]]
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[[Category: pneumococcal histidine triad protein]]
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[[Category: s pneumoniae]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 02:25:43 2008''
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Current revision

1.2 A Crystal structure of the S. pneumoniae PhtA histidine triad domain a novel zinc binding fold

PDB ID 2cs7

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